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Baicalein inhibits the pharmacokinetics of simvastatin in rats via regulating the activity of CYP3A4

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Baicalein and simvastatin possess similar pharmacological activities and indications. The risk of their co-administration was unclear. Objecti......

Therapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Sheng Xue Fang (SXF) has been used to treat anaemia for decades with good efficacy. Objective To study the effect and possible mechanism of SX......

Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood-brain barrier pathway

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Valeriana jatamansi Jones [syn. V. wallichii DC, (Valerianaceae)] (VJJ) is used to treat depression. Objective To explore the effects of total......

Antithrombotic effects of Huanglian Jiedu decoction in a rat model of ischaemia-reperfusion-induced cerebral stroke

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Huanglian Jiedu Decoction (HLJJD) has a variety of pharmacological activities, such as anti-inflammatory and neuroprotection against ischaemic......

Modified BuShenYiQi formula alleviates experimental allergic asthma in mice by negative regulation of type 2 innate lymphoid cells and CD4(+) type 9 helper T cells and the VIP-VPAC2 signalling pathway

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Modified BuShenYiQi formula (M-BYF) is derived from BuShenYiQi formula, used for the treatment of allergic asthma. The exact effect and mechan......

The safety and tolerability of alkaloids from Alstonia scholaris leaves in healthy Chinese volunteers: a single-centre, randomized, double-blind, placebo-controlled phase I clinical trial

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Capsule of alkaloids from the leaf of Alstonia scholaris (L.) R.Br. (Apocynaceae) (CALAS) is a new investigational botanical drug (No. 2011L01......

Alisol A 24-acetate protects oxygen-glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the B-cell lymphoma-2 gene

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Alisol A 24-acetate has been used to treat vascular diseases. However, the underlying mechanisms still remain unclear. Objective The present s......

Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl4/2-AAF

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Our previous studies indicated that Yiguanjian decoction (YGJ) has an anti-hepatic-fibrosis effect and could regulate macrophage status. Objec......

Saponins from Panax japonicus attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Panax japonicus is the dried rhizome of Panax japonicus C.A. Mey. (Araliaceae). Saponins from Panax japonicus (SPJ) exhibit anti-inflammatory ......

A pharmacokinetics-pharmacodynamics study of single-dose total glucosides of paeony capsule on reducing serum total bile acid in hepatic injury rats

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Total Glucosides of Paeony (TGP) capsule possesses various hepatoprotective activities. No study is available concerning TGP's concentration-e......

Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context After being steamed, the restorative effects of Panax notoginseng (Burk.) F. H. Chen (Araliaceae) will be strengthened. However, the underlyin......

Methyl-beta-cyclodextrin suppresses the monocyte-endothelial adhesion triggered by lipopolysaccharide (LPS) or oxidized low-density lipoprotein (oxLDL)

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Recent studies demonstrated the anti-atherosclerotic efficacy of cyclodextrin. However, it remains unclear whether cyclodextrin exerts the ant......

Anti-allergic actions of a Chinese patent medicine, huoxiangzhengqi oral liquid, in RBL-2H3 cells and in mice

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Huoxiangzhengqi oral liquid (HXZQ-OL), a traditional Chinese medicine formula, has antibacterial, anti-inflammation and gastrointestinal motil......

Simiao Qingwen Baidu decoction inhibits Epstein-Barr virus-induced B lymphoproliferative disease and lytic viral replication

期刊: PHARMACEUTICAL BIOLOGY, 2021; 59 (1)

Context Simiao Qingwen Baidu decoction (SQBD), a traditional Chinese medicine prescription, can ameliorate Epstein-Barr virus (EBV) induced disease. H......

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