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An integrated tumor, immune and microbiome atlas of colon cancer

期刊: NATURE MEDICINE, 2023; 29 (5)

The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In......

A reinforcement learning model for AI-based decision support in skin cancer

期刊: NATURE MEDICINE, 2023; 29 (8)

We investigated whether human preferences hold the potential to improve diagnostic artificial intelligence (AI)-based decision support using skin canc......

Efficacy estimates of oral pre-exposure prophylaxis for HIV prevention in cisgender women with partial adherence

期刊: NATURE MEDICINE, 2023; ()

Pre-exposure prophylaxis (PrEP) with tenofovir (TFV) disoproxil fumarate and emtricitabine administered orally daily is effective in preventing human ......

The transcriptional and regulatory identity of erythropoietin producing cells

期刊: NATURE MEDICINE, 2023; 29 (5)

Erythropoietin (Epo) is the master regulator of erythropoiesis and oxygen homeostasis. Despite its physiological importance, the molecular and genomic......

Rethinking placebos: embracing synthetic control arms in clinical trials for rare tumors

期刊: NATURE MEDICINE, 2023; ()

External comparator arms should be used when investigating novel therapies for gastrointestinal stromal tumor and other rare tumors to facilitate drug......

In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

期刊: NATURE MEDICINE, 2023; 29 (3)

Despite scientific evidence originating from two patients published to date that CCR5 Delta 32/Delta 32 hematopoietic stem cell transplantation (HSCT)......

A deep-learning algorithm to classify skin lesions from mpox virus infection

期刊: NATURE MEDICINE, 2023; 29 (3)

A deep-learning algorithm was developed to identify skin lesions caused by the mpox virus and was then implemented in a web-based app designed for pat......

Genetic association analysis of 77,539 genomes reveals rare disease etiologies

期刊: NATURE MEDICINE, 2023; 29 (3)

A flexible and compact database containing rare variant genotypes and phenotypes of 77,539 participants sequenced by the 100,000 Genomes Project enabl......

Phenotypic effects of genetic variants associated with autism

期刊: NATURE MEDICINE, 2023; 29 (7)

While over 100 genes have been associated with autism, little is known about the prevalence of variants affecting them in individuals without a diagno......

Polygenic prediction of preeclampsia and gestational hypertension

期刊: NATURE MEDICINE, 2023; 29 (6)

A multi-ancestry genetic meta-analysis identifies 12 new loci associated with preeclampsia and gestational hypertension and proposes the integration o......

Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials

期刊: NATURE MEDICINE, 2023; 29 (6)

Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate its treatment. AEF0117, the first of a new pharmacological cl......

Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results

期刊: NATURE MEDICINE, 2023; 29 (5)

Neuroblastomas harbor ALK aberrations clinically resistant to crizotinib yet sensitive pre-clinically to the third-generation ALK inhibitor lorlatinib......

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses

期刊: NATURE MEDICINE, 2023; 29 (7)

Depression is a common psychiatric disorder and a leading cause of disability worldwide. Here we conducted a genome-wide association study meta-analys......

Motixafortide and G-CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: a randomized phase 3 trial

期刊: NATURE MEDICINE, 2023; ()

Autologous hematopoietic stem cell transplantation (ASCT) improves survival in multiple myeloma (MM). However, many individuals are unable to collect ......

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