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Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis

期刊: PROTEIN & CELL, 2022; 13 (10)

Senescence, a stable state of growth arrest, affects many physiological and pathophysiological processes, especially aging. Previous work has indicate......

JIF:6.167

The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics

期刊: PROTEIN & CELL, 2022; 13 (9)

Extracellular vesicles (EVs) are tiny biological nanovesicles ranging from approximately 30-1000 nm in diameter that are released into the extracellul......

JIF:6.167

A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis

期刊: PROTEIN & CELL, 2022; 13 (3)

Zn2+ is required for the activity of many mitochondrial proteins, which regulate mitochondrial dynamics, apoptosis and mitophagy. However, it is not u......

JIF:6.167

Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome

期刊: PROTEIN & CELL, 2022; 13 (3)

Many people affected by fragile X syndrome (FXS) and autism spectrum disorders have sensory processing deficits, such as hypersensitivity to auditory,......

JIF:6.167

Targeting papain-like protease for broad-spectrum coronavirus inhibition

期刊: PROTEIN & CELL, 2022; 13 (12)

The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus epidemics in the past two decades emphasize the need for next-ge......

JIF:6.167

Cancer biology deciphered by single-cell transcriptomic sequencing

期刊: PROTEIN & CELL, 2022; 13 (3)

Tumors are complex ecosystems in which heterogeneous cancer cells interact with their microenvironment composed of diverse immune, endothelial, and st......

JIF:6.167

BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding

期刊: PROTEIN & CELL, 2022; 13 (8)

Chemically defined medium is widely used for culturing mouse embryonic stem cells (mESCs), in which N2B27 works as a substitution for serum, and GSK3 ......

JIF:6.167

Postnatal state transition of cardiomyocyte as a primary step in heart maturation

期刊: PROTEIN & CELL, 2022; 13 (11)

Postnatal heart maturation is the basis of normal cardiac function and provides critical insights into heart repair and regenerative medicine. While s......

JIF:6.167

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

期刊: PROTEIN & CELL, 2022; 13 (12)

SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries, however, the underlying mechanism, in particular i......

JIF:6.167

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