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Utility of incorporating next-generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and cost-effectiveness analysis

期刊: LUNG CANCER, 2020; 139 ()

Objectives: There is an expanding list of therapeutically relevant biomarkers for non-small cell lung cancer (NSCLC), and molecular profiling at diagn......

Trends in lung cancer risk and screening eligibility affect overdiagnosis estimates

期刊: LUNG CANCER, 2020; 139 ()

Objectives: The degree of overdiagnosis due to lung cancer screening in the general US population remains unknown. Estimates may be influenced by the ......

Final progression-free survival results from the J-ALEX study of alectinib versus crizotinib in ALK-positive non-small-cell lung cancer

期刊: LUNG CANCER, 2020; 139 ()

Objectives: The J-ALEX study compared the efficacy and safety of alectinib with crizotinib in Japanese patients with advanced ALK-positive non-small-c......

Development, validation and results from the impact of treatment evolution in non-small cell lung cancer (iTEN) model

期刊: LUNG CANCER, 2020; 139 ()

Objectives: Treatment of advanced NSCLC (aNSCLC) is rapidly evolving, as new targeted and immuno-oncology (I-O) treatments become available. The iTEN ......

Targeting ROR1 in combination with pemetrexed in malignant mesothelioma cells

期刊: LUNG CANCER, 2020; 139 ()

Objective: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is overexpressed in a subset of malignant cells. However, it remains unknown whether......

Clinical response to crizotinib and emergence of resistance in lung adenocarcinoma harboring a MET c-Cbl binding site mutation

期刊: LUNG CANCER, 2020; 139 ()

Objectives: MET c-Cbl binding site mutations constitute about 2 % of MET exon 14 alterations in lung cancer. Preclinical data suggests regarding these......

Molecular profiling of thymoma with myasthenia gravis: Risk factors of developing myasthenia gravis in thymoma patients

期刊: LUNG CANCER, 2020; 139 ()

Objective: Thymoma is a rare epithelial tumor arising from the thymus in the anterior mediastinum. Nearly 50% of patients with thymoma develop myasthe......

The utility of endosonography for mediastinal staging of non-small cell lung cancer in patients with radiological N0 disease

期刊: LUNG CANCER, 2020; 139 ()

Objectives: Recent practice guidelines recommend endosonography for patients with radiological N0 non-small cell lung cancer (NSCLC) when the primary ......

PLEKHM2-ALK: A novel fusion in small-cell lung cancer and durable response to ALK inhibitors

期刊: LUNG CANCER, 2020; 139 ()

Objectives: In non-small cell lung cancer (NSCLC), anaplastic lymphoma kinase (ALK) rearrangement identifies a subgroup of patients who are sensitive ......

The impact of body mass index on the efficacy of anti-PD-1/PD-L1 antibodies in patients with non-small cell lung cancer

期刊: LUNG CANCER, 2020; 139 ()

Objectives: : Body mass index (BMI) is reported to be associated with the efficacy of immune checkpoint inhibitors (ICIs) in solid tumors such as mela......

Uncommon EGFR mutations associate with lower incidence of T790M mutation after EGFR-TKI treatment in patients with advanced NSCLC

期刊: LUNG CANCER, 2020; 139 ()

Objectives: Advanced non-small cell lung cancer (NSCLC) patients harboring non-resistant uncommon epidermal growth factor receptor (EGFR) mutations ha......

Detection of TGF-beta in pleural effusions for diagnosis and prognostic stratification of malignant pleural mesothelioma

期刊: LUNG CANCER, 2020; 139 ()

Objectives: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with dismal prognosis but variable course of disease. To support diagnosi......

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