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Quantitative analysis of metabolites in glucose metabolism in the aqueous humor of patients with central retinal vein occlusion

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 191 ()

Quantitative analysis of aqueous humor (AH) was performed to investigate glucose metabolism in patients with central retinal vein occlusion (CRVO), an......

Involvement of regulated necrosis in blinding diseases: Focus on necroptosis and ferroptosis

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 191 ()

Besides apoptosis, necrosis can also occur in a highly regulated and genetically controlled manner, defined as regulated necrosis, which is characteri......

COL2A1 protective variant reduces sporadic rhegmatogenous retinal detachment severity

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 191 ()

Rhegmatogenous retinal detachment (RRD) is the most common type of RD, the separation of neurosensory retina from the underlying retinal pigment epith......

Therapeutic effects of mesenchymal stem cell-derived exosomes on retinal detachment

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 191 ()

Retinal detachment (RD) induces ischemia and oxygen deficiency in the retina and results in multiple pathological events; photoreceptor cell degenerat......

Human umbilical cord mesenchymal stem cells alleviate ongoing autoimmune dacryoadenitis in rabbits via polarizing macrophages into an anti-inflammatory phenotype

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 191 ()

Mesenchymal stem cells (MSCs) exhibit beneficial effects on autoimmune dacryoadenitis. However, the underlying mechanisms are not fully understood. In......

Molecular genetics of congenital cataracts

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 191 ()

Congenital cataracts, the most common cause of visual impairment and blindness in children worldwide, have diverse etiologies. According to statistics......

Gut microbiota compositional profile and serum metabolic phenotype in patients with primary open-angle glaucoma

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 191 ()

The gut microbiota (GM) and its influence on host metabolism are considered to be an environmental factor that contributes to the progression of many ......

High-throughput transcriptional profiling combined with angiogenesis antibody array analysis in an orbital venous malformation cohort

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 191 ()

Orbital venous malformations (OVMs) are the most common benign orbital vascular disorders in adults and are characterized as enlarging encapsulated va......

Gypenosides mediate cholesterol efflux and suppress oxidized LDL induced inflammation in retinal pigment epithelium cells

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 191 ()

Age-related macular degeneration (AMD) is a predominant cause of visual deficit in aged population. Abnormal accumulation of cholesterol, including ox......

Two-year observation of morphologic and histopathologic changes in the monkey cornea following small incision allogenic lenticule implantation

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 192 ()

Purpose: To observe the morphologic and histopathologic changes of femtosecond laser assisted small incision allogenic intrastromal lenticule implanta......

Circular RNA-ZNF609 regulates corneal neovascularization by acting as a sponge of miR-184

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 192 ()

Corneal neovascularization can cause abnormal blood vessels to grow in the normally transparent and translucent cornea leading to various sight-threat......

Impact of PTEN/SOCS3 deletion on amelioration of dendritic shrinkage of retinal ganglion cells after optic nerve injury

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 192 ()

Retinal ganglion cell (RGC) degeneration, leading to irreversible blindness in chronic optic neuropathies, commonly begins with dendritic shrinkage fo......

Protective effect inhibiting the expression of miR-181a on the diabetic corneal nerve in a mouse model

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 192 ()

To investigate the protective effect of inhibiting miR-181a on diabetic corneal nerve in mice, we chose male C57BL/6 mice with streptozotocin (STZ) -i......

Dynamic spatiotemporal expression pattern of limbal stem cell putative biomarkers during mouse development

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 192 ()

Limbal stem cells (LSCs), a subpopulation of limbal epithelial basal cells, are crucial to the homeostasis and wound healing of corneal epithelium. Th......

The spectrum of genetic mutations in patients with asymptomatic mild familial exudative vitreoretinopathy

期刊: EXPERIMENTAL EYE RESEARCH, 2020; 192 ()

Familial exudative vitreoretinopathy (FEVR) is a disease exhibits a wide range of clinical signs, ranging mild peripheral retinal vascular anomalies t......

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