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Plasma Short-Chain Fatty Acids Differences in Multiple System Atrophy from Parkinson's Disease

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (3)

Background: Multiple system atrophy (MSA) and Parkinson's disease (PD) have overlapping symptoms, making diagnosis challenging. Short-chain fatty acid......

Six-Month Community-Based Brisk Walking and Balance Exercise Alleviates Motor Symptoms and Promotes Functions in People with Parkinson's Disease: A Randomized Controlled Trial

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (3)

Background: In Parkinson's disease (PD), sustained aerobic exercise is a promising therapy in delaying motor disability. Brisk walking is a moderate i......

Non-Genetic Risk Factors for Parkinson's Disease: An Overview of 46 Systematic Reviews

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (3)

Background: Numerous systematic reviews (SRs) and meta-analyses on non-genetic risk factors for Parkinson's disease (PD) development have been publish......

Neuroprotective Effects of a GLP-2 Analogue in the MPTP Parkinson's Disease Mouse Model

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (2)

Background: Glucagon-like peptide 2 (GLP-2) is a peptide hormone derived from the proglucagon gene expressed in the intestines, pancreas and brain. So......

Subthalamic Stimulation for Camptocormia in Parkinson's Disease: Association of Volume of Tissue Activated and Structural Connectivity with Clinical Effectiveness

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (1)

Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) has been reported to be effective for camptocormia in Parkinson's disease (PD)......

Neuroticism, Smoking, and the Risk of Parkinson's Disease

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (3)

Background: The relationship among neuroticism, smoking, and Parkinson's disease (PD) is less examined. Objective: To examine the causal associations ......

Serum Neurofilament Dynamics Predicts Cognitive Progression in de novo Parkinson's Disease

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (3)

Background: Neurofilament light (NfL) can reflect the extent of neuron/axon damage, thus providing an opportunity to examine the severity and progress......

Low Sustainment of High-Dose Oral Medication Regimens for Advanced Parkinson's Disease in Medicare Beneficiaries

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (2)

Background: Increasing doses of oral antiparkinson medications are indicated in advanced Parkinson's disease (PD), but little is known about sustainme......

Non-Motor Features of Parkinson's Disease in Women

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (3)

Background: Non-motor symptoms are common in Parkinson's disease (PD) and some, including hyposmia, constipation, and REM sleep behavior disorder, oft......

Genetics of Progressive Supranuclear Palsy: A Review

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (1)

Progressive supranuclear palsy (PSP) is an atypical parkinsonism with prominent 4R-tau neuropathology, and the classical clinical phenotype is charact......

Diet Quality and Risk of Parkinson's Disease: A Prospective Study and Meta-Analysis

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (1)

Background: Several dietary components have been shown to be neuroprotective against risk of neurodegeneration. However, limited observational studies......

Lack of Association of Locus Coeruleus Pathology with Orthostatic Hypotension in Parkinson's Disease

期刊: JOURNAL OF PARKINSONS DISEASE, 2021; 11 (1)

Orthostatic hypotension (OH) is a common non-motor symptom in Parkinson's disease (PD) and is linked with increased mortality risk among the elderly. ......

Cognitive Function and Quality of Life in Parkinson's Disease: A Cross-Sectional Study

期刊: JOURNAL OF PARKINSONS DISEASE, 2020; 10 (3)

Background: Parkinson's disease with mild cognitive impairment (PD-MCI) or dementia (PDD) has been shown to be correlated with poor quality of life (Q......

SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease

期刊: JOURNAL OF PARKINSONS DISEASE, 2020; 10 (3)

Background: alpha-Synuclein has been related to the pathogenesis of Parkinson's disease (PD), but it has not thoroughly been investigated in idiopathi......

Fasudil Promotes alpha-Synuclein Clearance in an AAV-Mediated alpha-Synuclein Rat Model of Parkinson's Disease by Autophagy Activation

期刊: JOURNAL OF PARKINSONS DISEASE, 2020; 10 (3)

Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder, but the disease-modifying therapies focusing on the core pa......

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