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Protein arginine methylation: from enigmatic functions to therapeutic targeting

期刊: NATURE REVIEWS DRUG DISCOVERY, ; ()

Protein arginine methyltransferases (PRMTs) regulate numerous biological processes, including transcription, splicing and the DNA damage response. In ......

Beyond immune checkpoint blockade: emerging immunological strategies

期刊: NATURE REVIEWS DRUG DISCOVERY, ; ()

Although checkpoint inhibitor blockade has been extremely successful in certain types of cancer, harnessing the immune system for immunosurveillance h......

Channelling inflammation: gasdermins in physiology and disease

期刊: NATURE REVIEWS DRUG DISCOVERY, ; ()

Gasdermins were recently identified as the mediators of pyroptosis - inflammatory cell death triggered by cytosolic sensing of invasive infection and ......

Circadian rhythm as a therapeutic target

期刊: NATURE REVIEWS DRUG DISCOVERY, ; ()

Disregulation of circadian rhythms, as a result of jet lag or other lifestyle factors, can increase the risks of certain diseases. This Review analyse......

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

期刊: NATURE REVIEWS DRUG DISCOVERY, 2020; 19 (3)

Therapeutic options in response to the 2019-nCoV outbreak are urgently needed. Here, we discuss the potential for repurposing existing antiviral agent......

Therapeutic strategies for hepatitis B virus infection: towards a cure

期刊: NATURE REVIEWS DRUG DISCOVERY, 2019; 18 (11)

Chronic hepatitis B virus (HBV) infection is a common cause of liver disease globally, with a disproportionately high burden in South-East Asia. Vacci......

JIF:57.62

Turning foes to friends: targeting cancer-associated fibroblasts

期刊: NATURE REVIEWS DRUG DISCOVERY, 2019; 18 (2)

Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the malignancy, as the cancer stroma may prompt tumour relaps......

JIF:57.62

Lessons from immuno-oncology: a new era for cancer nanomedicine?

期刊: NATURE REVIEWS DRUG DISCOVERY, 2017; 16 (6)

Despite a decade of intensive preclinical research, the translation of cancer nanomedicine to the clinic has been slow. Here, we discuss how recent le......

JIF:50.17

Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets

期刊: NATURE REVIEWS DRUG DISCOVERY, 2017; 16 (1)

Mesenchymal stem cells, also known as mesenchymal stromal cells (MSCs), exist in many tissues and are known to actively migrate to sites of tissue inj......

JIF:50.17

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