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microRNA-133a exerts tumor suppressive role in oral squamous cell carcinoma through the Notch signaling pathway via downregulation of CTBP2

期刊: CANCER GENE THERAPY, 2022; 29 (1)

microRNAs (miRNAs) have been revealed to participate in some oral cancers and are proved to be effective. In the present study, we tried to explore th......

JIF:4.883

DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-kappa Beta-IRF1-CIITA pathway

期刊: CANCER GENE THERAPY, 2022; 29 (2)

Major histocompatibility complex class II (MHC II) is important for the adaptive immune response because MHC II presents processed antigens to a clust......

JIF:4.883

Radiation enhances the delivery of antisense oligonucleotides and improves chemo-radiation efficacy in brain tumor xenografts

期刊: CANCER GENE THERAPY, 2022; 29 (5)

Overexpression of O-6-methylguanine DNA methyltransferase (MGMT) contributes to resistance to chemo-radiation therapy (CRT) in brain tumors. We previo......

JIF:4.883

Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer

期刊: CANCER GENE THERAPY, 2022; 29 (6)

CDK4/6 inhibitors significantly prolong progression-free survival in patients with advanced hormone receptor-positive (HR+) HER2-negative breast cance......

JIF:4.883

FCH domain only 1 (FCHo1), a potential new biomarker for lung cancer

期刊: CANCER GENE THERAPY, 2022; 29 (7)

Lung carcinoma is the main reason for cancer-associated deaths in the world. In a previous study, FCH domain only 1 (FCHo1) which is managed by protei......

JIF:4.883

Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1

期刊: CANCER GENE THERAPY, 2022; 29 (1)

Significantly high-expressed circFLNA has been found in various cancer cell lines, but not in lung cancer. Therefore, this study aimed to explore the ......

JIF:4.883

LncRNA MAFG-AS1 promotes the malignant phenotype of ovarian cancer by upregulating NFKB1-dependent IGF1

期刊: CANCER GENE THERAPY, 2022; 29 (3-4)

Long non-coding RNAs (lncRNAs) were recently recognized to vitally function in a variety of cancer cellular events, including epithelial-mesenchymal t......

JIF:4.883

CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy

期刊: CANCER GENE THERAPY, 2022; 29 (6)

Immunotherapeutic strategies that combine oncolytic virus (OV) and immune checkpoint inhibitors have the potential to overcome treatment resistance in......

JIF:4.883

Homeostatic cytokines tune naivety and stemness of cord blood-derived transgenic T cells

期刊: CANCER GENE THERAPY, 2022; 29 (7)

Engineered T-cell therapies have proven to be successful in cancer and their clinical effectiveness is directly correlated with the infused T-cell dif......

JIF:4.883

Aberrant DNA methylation impacts HOX genes expression in bone marrow mesenchymal stromal cells of myelodysplastic syndromes and de novo acute myeloid leukemia

期刊: CANCER GENE THERAPY, 2022; 29 (8-9)

DNA methylation, a major biological process regulating the transcription, contributes to the pathophysiology of hematologic malignancies, and hypometh......

JIF:4.883

Systems analysis identifies endothelin 1 axis blockade for enhancing the anti-tumor effect of multikinase inhibitor

期刊: CANCER GENE THERAPY, 2022; 29 (6)

Multikinase inhibitors, such as sorafenib, are used for the treatment of advanced carcinomas but the response shows limited efficacy or varies a lot w......

JIF:4.883

Non-classical Notch signaling by MDA-MB-231 breast cancer cell-derived small extracellular vesicles promotes malignancy in poorly invasive MCF-7 cells

期刊: CANCER GENE THERAPY, 2022; 29 (7)

Aberrant Notch signaling is implicated in breast cancer progression, and recent studies have demonstrated links between the Notch pathway components N......

JIF:4.883

CRHBP is degraded via autophagy and exerts anti-hepatocellular carcinoma effects by reducing cyclin B2 expression and dissociating cyclin B2-CDK1 complex

期刊: CANCER GENE THERAPY, 2022; 29 (8-9)

Autophagy is the predominant self-eating catabolic pathway activated in response to nutrient starvation and hypoxia within the microenvironment of var......

JIF:4.883

Harnessing Rift Valley fever virus NSs gene for cancer gene therapy

期刊: CANCER GENE THERAPY, 2022; 29 (10)

One of the greatest challenges in the treatment of cancer is tumor heterogeneity which results in differential responses to chemotherapy and drugs tha......

JIF:4.883

Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4

期刊: CANCER GENE THERAPY, 2022; 29 (11)

Drug resistance is a key factor in the treatment failure of acute myeloid leukemia (AML). Nuclear factor E2-related factor 2 (Nrf2) plays a crucial ro......

JIF:4.883

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