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Loss of cannabinoid receptor 2 promotes α-Synuclein-induced microglial synaptic pruning in nucleus accumbens by modulating the pCREB-c-Fos signaling pathway and complement system

期刊: EXPERIMENTAL NEUROLOGY, 2023; 359 ()

The disruption of nucleus accumbens (NAc) function impacts mood and learning behavior in alpha-Synucleinopathy, in which microglial synaptic pruning p......

The cannabinoid CB1 receptor interacts with the angiotensin AT2 receptor. Overexpression of AT2-CB1 receptor heteromers in the striatum of 6-hydroxydopamine hemilesioned rats

期刊: EXPERIMENTAL NEUROLOGY, 2023; 362 ()

It is of particular interest the potential of cannabinoid and angiotensin receptors as targets in the therapy of Parkinson's disease (PD). While endoc......

Cortical spreading depolarization is a potential target for rat brain excitability modulation by Galanin

期刊: EXPERIMENTAL NEUROLOGY, 2023; 370 ()

The inhibitory neuropeptide Galanin (Gal) has been shown to mediate anticonvulsion and neuroprotection. Here we investigated whether Gal affects corti......

3D culture of the spinal cord with roots as an ex vivo model for comparative studies of motor and sensory nerve regeneration

期刊: EXPERIMENTAL NEUROLOGY, 2023; 362 ()

Motor and sensory nerves exhibit tissue-specific structural and functional features. However, in vitro models designed to reflect tissue-specific diff......

The effect of gastric bypass surgery on cognitive function of Alzheimer's disease and the role of GLP1-SGLT1 pathway

期刊: EXPERIMENTAL NEUROLOGY, 2023; 363 ()

Objective: Gastric bypass surgery has been shown to improve metabolic profiles via GLP1, which may also have cognitive benefits for Alzheimer's diseas......

Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia

期刊: EXPERIMENTAL NEUROLOGY, 2023; 367 ()

Neonatal hypoxic-ischemic encephalopathy (HIE) is the primary reason for neonatal mortality and prolonged disablement. Currently, hypothermia is the o......

The relationship between long non-coding RNAs and Wnt/ß-catenin signaling pathway in the pathogenesis of Alzheimer's disease

期刊: EXPERIMENTAL NEUROLOGY, 2023; 366 ()

Long non-coding RNAs (lncRNAs) cannot be coded to proteins; however, they can display important functions in several aspects of cell biology. Their ab......

Glypican-2 defines age-dependent axonal response to chondroitin sulfate

期刊: EXPERIMENTAL NEUROLOGY, 2023; 366 ()

Axons of terminally differentiated neurons in the mammalian central nervous system (CNS) are unable to regenerate after dissection. One of the mechani......

MiR-34a targets SIRT1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice

期刊: EXPERIMENTAL NEUROLOGY, 2023; 368 ()

This study is to investigate the function of miR-34a and interactions between miR-34a, SIRT1, and p53 in sevoflurane-induced neuronal apoptosis and au......

Blockage of calcium-sensing receptor improves chronic intermittent hypoxia-induced cognitive impairment by PERK-ATF4-CHOP pathway

期刊: EXPERIMENTAL NEUROLOGY, 2023; 368 ()

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is involved in cognitive impairment of children. Chronic intermittent hypoxia (CIH) is considered as......

TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction

期刊: EXPERIMENTAL NEUROLOGY, 2023; 369 ()

Autophagy is considered a double-edged sword, with a role in the regulation of the pathophysiological processes of the central nervous system (CNS) af......

The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 x Tg-AD) mouse model strain

期刊: EXPERIMENTAL NEUROLOGY, 2023; 368 ()

As a classic animal model of Alzheimer's disease (AD), the 3 x Tg-AD mouse not only recapitulates most of anatomical hallmarks observed in AD patholog......

Ischemic stroke rehabilitation through optogenetic modulation of parvalbumin neurons in the contralateral motor cortex

期刊: EXPERIMENTAL NEUROLOGY, 2023; 360 ()

Background: Based on the theory of interhemispheric inhibition and the bimodal balance-recovery model in stroke, we explored the effects of excitation......

MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage

期刊: EXPERIMENTAL NEUROLOGY, 2023; 362 ()

Hypoxic-ischemic brain damage (HIBD) is one of the major causes of infant death and long-term neurological disturbances, which puts great pressure on ......

The original strain of SARS-CoV-2, the Delta variant, and the Omicron variant infect microglia efficiently, in contrast to their inability to infect neurons: Analysis using 2D and 3D cultures

期刊: EXPERIMENTAL NEUROLOGY, 2023; 363 ()

COVID-19 causes neurological damage, systemic inflammation, and immune cell abnormalities. COVID-19induced neurological impairment may be caused by se......

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