In this issue of Structure, Healy et al. discovered the PDLIM family of proteins as novel interactors of the sort-ing nexin SNX17, determined the NMR ......
Telomerase is crucial for telomere maintenance and genome integrity. The most salient feature of Tetrahy-mena telomerase is that its CST subcomplex (p......
Drosophila TRP is a calcium-permeable cation channel essential for fly visual signal transduction. During phototransduction, Ca2+ mediates both positi......
Integrin activation controls cell adhesion, migration, invasion, and extracellular matrix remodeling. RIAM (RAP1-GTP-interacting adaptor molecule) is ......
The abnormal amplification of a CAG repeat in the gene coding for huntingtin (HTT) leads to Huntington's disease (HD). At the protein level, this tran......
By using P-31 NMR, we present evidence that the Rho family GTPase RhoA, similar to Ras GTPases, exists in an equilibrium of conformations when bound t......
Ligands bind to an occluded orthosteric ligand-binding pocket within the nuclear receptor ligand- binding domain. Molecular simulations have revealed ......
The Saccharomyces cerevisiae respiratory supercomplex factor 2 (Rcf2) is a 224-residue protein located in the mitochondrial inner membrane where it is......
Tyrosine kinase receptor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) bind to hormones, such as insulin, IGF-1, and IGF......
Centrioles are cylindrical assemblies whose peripheral microtubule array displays a 9-fold rotational symmetry that is established by the scaffolding ......
CASK forms an evolutionarily conserved tripartite complex with Mint1 and Veli critical for neuronal synaptic transmission and cell polarity. The CASK ......
The small protein AcrZ in Escherichia coli interacts with the transmembrane portion of the multidrug efflux pump AcrB and increases resistance of the ......
Pathogenesis of anthrax disease involves two cytotoxic enzymes-edema factor (EF) and lethal factor (LF)- which are individually recruited by the prote......
Chemical crosslinking coupled with mass spectrometry (CXMS) has been increasingly used in structural biology. CXMSdistance restraints are usually appl......
KMT2 family methyltransferases methylate histone H3 lysine 4 and play essential roles inmultiple cellular processes. MLL2 (KMT2B) is required for earl......
