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Implications of cancer stem cells in diabetes and pancreatic cancer

期刊: LIFE SCIENCES, 2023; 312 ()

This review provides a detailed study of pancreatic cancer (PC) and the implication of different types of cancers concerning diabetes. The combination......

Effects of NAC assisted insulin on cholesterol metabolism disorders in canine type 1 diabetes mellitus

期刊: LIFE SCIENCES, 2023; 313 ()

Type 1 diabetes mellitus (T1DM) is a metabolic disease characterized by insulin deficiency and often accom-panied by hypercholesterolemia. NAC is an e......

Antibacterial activity and metabolomic analysis of linalool against bovine mastitis pathogen Streptococcus agalactiae

期刊: LIFE SCIENCES, 2023; 313 ()

Streptococcus agalactiae is among the major causative pathogens of bovine mastitis, as well as crucial pathogen leading to human morbidity and mortali......

Preliminary investigation on impact of intergenerational treatment of resveratrol endorses the development of 'super-pups'

期刊: LIFE SCIENCES, 2023; 314 ()

Background: Redox biology balances free radical generation and scavenging systems, whereas an imbalanced cellular redox can hasten the onset of variou......

MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBP? modification in rats

期刊: LIFE SCIENCES, 2023; 315 ()

Aims: To determine the effects of the mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTSc) and aerobic exercise on cardiac structu......

Kinins and their B1 and B2 receptors as potential therapeutic targets for pain relief

期刊: LIFE SCIENCES, 2023; 314 ()

Kinins are endogenous peptides that belong to the kallikrein-kinin system, which has been extensively studied for over a century. Their essential role......

Adipocyte-hepatocyte crosstalk in cellular models of obesity: Role of soluble factors

期刊: LIFE SCIENCES, 2023; 317 ()

Hepatic steatosis is often a consequence of obesity. Adipose tissue is an important endocrine regulator of metabolic homeostasis in the body. In obesi......

TRPV1 is involved in abdominal hyperalgesia in a mouse model of lipopolysaccharide-induced peritonitis and influences the immune response via peripheral noradrenergic neurons

期刊: LIFE SCIENCES, 2023; 317 ()

Aims: The transient receptor potential vanilloid subfamily 1 (TRPV1) not only plays a role as a nociceptor but also has some regulatory effects on the......

A novel approach to repositioning memantine for metabolic syndrome-induced steatohepatitis: Modulation of hepatic autophagy, inflammation, and fibrosis

期刊: LIFE SCIENCES, 2023; 319 ()

Aims: This study investigated the possible hepatoprotective effects of memantine, compared to pioglitazone, in rat steatohepatitis, emphasizing its ro......

Therapeutic application of mesenchymal stem cells derived exosomes in neurodegenerative diseases: A focus on non-coding RNAs cargo, drug delivery potential, perspective

期刊: LIFE SCIENCES, 2023; 320 ()

Despite the massive efforts advanced over recent years in emerging therapies for neurodegenerative diseases, effective treatment for these diseases is......

Placental ischemia disrupts DNA methylation patterns in distal regulatory regions in rats

期刊: LIFE SCIENCES, 2023; 321 ()

Preeclampsia (PE) is a leading cause of maternal and fetal morbidity and mortality worldwide. However, the impact of PE on the organization of the fun......

Oxidative stress as a culprit in diabetic kidney disease

期刊: LIFE SCIENCES, 2023; 322 ()

Diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease (ESRD), and the prevalence of DKD has increased worldwide during......

EIF4A3-induced circZFAND6 promotes breast cancer proliferation and metastasis through the miR-647/FASN axis

期刊: LIFE SCIENCES, 2023; 324 ()

Aims: Circular RNAs (circRNAs) are important regulators in breast cancer progression. However, the underlying mechanism of circRNAs functions in breas......

Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota

期刊: LIFE SCIENCES, 2023; 324 ()

Aims: Inflammatory bowel disease (IBD) patients are accompanied by impaired intestinal barrier integrity and gut microbiota dysbiosis. Strategies targ......

Metabolic outcomes and changes in innate immunity induced by diesel exhaust particles airway exposure and high-fat high-sucrose diet

期刊: LIFE SCIENCES, 2023; 326 ()

Aims: Epidemiological studies have shown that exposure to diesel exhaust particles (DEP) is associated with metabolic diseases. We used mice with nona......

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