期刊： NATURE CELL BIOLOGY, 2022; 24 (8)
EGFR is an oncogene that is frequently amplified in glioblastoma. A new study suggests a tumour-suppressive role of EGFR in EGFR-amplified glioblastom......
期刊： NATURE CELL BIOLOGY, 2022; 24 (1)
Mirman et al. report that the primary function of the shieldin complex in double-strand break repair in BRCA1-deficient cells is the recruitment of th......
期刊： NATURE CELL BIOLOGY, 2022; 24 (3)
Transfer RNA-derived fragments (tRFs) are emerging small noncoding RNAs that, although commonly altered in cancer, have poorly defined roles in tumori......
期刊： NATURE CELL BIOLOGY, 2022; 24 (4)
Epithelial to mesenchymal transitions (EMTs) drive cancer metastases. A series of single cell analyses now reveal this change in state is not binary a......
期刊： NATURE CELL BIOLOGY, 2022; 24 (6)
Savini et al. report that lysosomal lipolysis in peripheral adipose depots produces polyunsaturated fatty acids (PUFAs). PUFAs and the lipid chaperone......
期刊： NATURE CELL BIOLOGY, 2022; 24 (11)
DYT1 dystonia is a debilitating neurological movement disorder arising from mutation in the AAA+ ATPase TorsinA. The hallmark of Torsin dysfunction is......
期刊： NATURE CELL BIOLOGY, 2022; 24 (2)
Wang, Qu et al. developed a genome-editing system, utilizing catalytically inactive Cas9 fused to microbial single-strand annealing proteins, for kilo......
期刊： NATURE CELL BIOLOGY, 2022; 24 (3)
Canonically, EZH2 serves as the catalytic subunit of PRC2, which mediates H3K27me3 deposition and transcriptional repression. Here, we report that in ......
期刊： NATURE CELL BIOLOGY, 2022; 24 (3)
Pancreatic ductal adenocarcinoma (PDAC) originates from normal pancreatic ducts where digestive juice is regularly produced. It remains unclear how PD......
期刊： NATURE CELL BIOLOGY, 2022; 24 (3)
Proliferation is a fundamental trait of cancer cells, but its properties and spatial organization in tumours are poorly characterized. Here we use hig......
期刊： NATURE CELL BIOLOGY, 2022; 24 (7)
Mutagenic purine-pyrimidine repeats can adopt the left-handed Z-DNA conformation. DNA breaks at potential Z-DNA sites can lead to somatic mutations in......
期刊： NATURE CELL BIOLOGY, 2022; 24 (9)
In this Review, Andrew Modzelewski, Johnny Gan Chong, Ting Wang and Lin He discuss how sequences introduced by transposon activities provide raw mater......
期刊： NATURE CELL BIOLOGY, 2022; 24 (11)
The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating immune cells and impedes durable clinical remission followin......
