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Arsenic trioxide-loaded CalliSpheres: In vitro study of drug release and antitumor activity, and in vivo study of pharmacokinetics, treatment efficacy and safety in liver cancer

期刊: ONCOLOGY REPORTS, 2021; 46 (1)

The aim of the present study was to investigate the arsenic trioxide (ATO) loading/releasing efficiency of CalliSphere beads (CBs), as well as the in ......

Mechanism of hydrogen on cervical cancer suppression revealed by high-throughput RNA sequencing

期刊: ONCOLOGY REPORTS, 2021; 46 (1)

Cervical cancer is considered one of the diseases with the highest mortality among women and with limited treatment options. Hydrogen (H-2) inhalation......

Role of reactive oxygen species in tumors based on the 'seed and soil' theory: A complex interaction

期刊: ONCOLOGY REPORTS, 2021; 46 (3)

Tumor microenvironment (TME) can serve as the 'soil' for the growth and survival of tumor cells and function synergically with tumor cells to mediate ......

Targeting USP22 with miR-30-5p to inhibit the hypoxia-induced expression of PD-L1 in lung adenocarcinoma cells

期刊: ONCOLOGY REPORTS, 2021; 46 (4)

Lung cancer is one of the most common forms of cancer and accounts for a significant proportion of all cancer-related deaths. Lung adenocarcinoma (LUA......

METTL3-mediated m6A modification of Bcl-2 mRNA promotes non-small cell lung cancer progression

期刊: ONCOLOGY REPORTS, 2021; 46 (2)

Methyltransferase-like 3 (METTL3) is an RNA methyltransferase that mediates modification of N6-methyladenosine (m6A), which serves as an oncogene in v......

Dehydrocrenatidine extracted from Picrasma quassioides induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways

期刊: ONCOLOGY REPORTS, 2021; 46 (2)

Nasopharyngeal carcinoma (NPC) is an indicator disease in Asia due to its unique geographical and ethnic distribution. Dehydrocrenatidine (DC) is a be......

Chronic stress promotes glioma cell proliferation via the PI3K/Akt signaling pathway

期刊: ONCOLOGY REPORTS, 2021; 46 (3)

High malignancy and high mortality of glioma render it urgent to elucidate the underlying mechanisms of glioma carcinogenesis and explore novel target......

Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45 alpha/JNK/c-Jun signalling pathway

期刊: ONCOLOGY REPORTS, 2021; 45 (6)

Colorectal cancer (CRC) is the third most diagnosed cancer worldwide. Progesterone is associated with a decreased risk of CRC and leads to a favourabl......

Vanillin downregulates NNMT and attenuates NNMT-related resistance to 5-fluorouracil via ROS-induced cell apoptosis in colorectal cancer cells

期刊: ONCOLOGY REPORTS, 2021; 45 (6)

Chemoresistance is the main cause of poor prognosis in colorectal cancer (CRC). Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that is ......

BET inhibitors combined with chemotherapy synergistically inhibit the growth of NSCLC cells

期刊: ONCOLOGY REPORTS, 2021; 45 (5)

The bromodomain and extra-terminal domain (BET) family proteins are essential epigenetic regulators in lung cancer. However, BET inhibitors have not h......

RHPN1-AS1 promotes ovarian carcinogenesis by sponging miR-485-5p and releasing TPX2 mRNA

期刊: ONCOLOGY REPORTS, 2021; 45 (6)

Long non-coding RNAs (lncRNAs) play a crucial role in cancer development. However, researchers have yet to identify the underlying association between......

Plasma-derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells

期刊: ONCOLOGY REPORTS, 2021; 46 (4)

Exosomal pyruvate kinase isoenzyme type M2 (PKM2) has been found to play a key role in the progression of human hepatocarcinoma. However, exosomal PKM......

miRNA-7515 suppresses pancreatic cancer cell proliferation, migration and invasion via downregulating IGF-1 expression

期刊: ONCOLOGY REPORTS, 2021; 46 (3)

Pancreatic cancer (PC) is a lethal malignancy of the gastrointestinal tract. Previous studies have reported that microRNAs (miRNAs/miRs) are involved ......

Schisandrin B inhibits epithelial-mesenchymal transition and stemness of large-cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF-kappa B and p38 MAPK signaling pathways

期刊: ONCOLOGY REPORTS, 2021; 45 (6)

Lung cancer is one of the most common types of cancer in the world, resulting in numerous cancer-associated deaths. The properties of cancer stem cell......

Interaction between CD9 and PI3K-p85 activates the PI3K/AKT signaling pathway in B-lineage acute lymphoblastic leukemia

期刊: ONCOLOGY REPORTS, 2021; 46 (1)

Our previous study has shown that CD9 knockdown could suppress cell proliferation, adhesion, migration and invasion, and promote apoptosis and the cyt......

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