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Amplicon-based NGS test for assessing MLH1 promoter methylation and its correlation with BRAF mutation in colorectal cancer patients

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2023; 130 ()

Detecting MLH1 promoter methylation is highly relevant to differentiate between possible Lynch syndrome patients or patients with sporadic causes of M......

Diversin upregulates the proliferative ability of colorectal cancer by inducing cell cycle proteins

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2023; 129 ()

Colorectal cancer (CRC) is a common gastrointestinal tumour with increasing incidence worldwide. However, the underlying molecular mechanism of CRC pr......

DNA methylation of HOX genes and its clinical implications in cancer

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2023; 134 ()

Homeobox (HOX) genes encode highly conserved transcription factors that play vital roles in embryonic development. DNA methylation is a pivotal regula......

Effects of bisphenol A on murine salivary glands and human tumor cell lines

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2023; 134 ()

Bisphenol A (BPA) is an endocrine-disrupting chemical with a potential role in endocrine cancers. However, the effects of BPA on the salivary glands h......

Inhibition of integrin alpha v/beta 5 mitigates the protective effect induced irisin in

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2023; 134 ()

Introduction: Irisin plays an important role in regulating tissue stress, cardiac function, and inflammation. Integrin alpha v beta 5 was recently ide......

Analysis of BRCA1 and BRCA2 alternative splicing in predisposition to ovarian cancer

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2023; 130 ()

Background: The mRNA splicing is regulated on multiple levels, resulting in the proper distribution of genes' transcripts in each cell and maintaining......

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2023; 131 ()

Cytokeratin 20 (CK20) expression is limited to umbrella cells in the normal urothelium. Since CK20 is often upregulated in neoplastic urothelial cells......

A review of the critical role of vitamin D axis on the immune system

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2023; 132 ()

In recent years, the physiological and molecular functions of vitamin D (Vit-D) have been deeply investigated. At first, Vit-D was considered a regula......

Urinary exosomes from patients with diabetic kidney disease induced podocyte apoptosis via microRNA-145-5p/Srgap2 and the RhoA/ ROCK pathway

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2023; 134 ()

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease without early diagnostic and specific therapeutic approaches. Podocyte apo......

The MC160 protein of the molluscum contagiosum virus dampens cGAS/ STING-induced interferon-β activation

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2023; 134 ()

Molluscum contagiosum virus (MCV) is a poxvirus that causes benign, persistent skin lesions. MCV encodes a variety of immune evasion molecules to damp......

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