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An ellagitannin-loaded CS-PEG decorated PLGA nano-prototype promotes cell cycle arrest in colorectal cancer cells

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; 81 (2)

Colorectal cancer is associated with significant morbidity and mortality worldwide. Egypt, as a developing country, has a high-rise incidence of cance......

Activation of Wnt Pathway Suppresses Growth of MUG-Chor1 Chordoma Cell Line

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; 81 (4)

Chordoma as a malignant bone tumor, occurs along the axial skeleton and does not have an effective therapy. Brachyury, which is a crucial player for t......

Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; 81 (1)

ATP-binding cassette transporter A-I (ABCA1) is an ubiquitously expressed protein whose main function is the transmembrane transport of cholesterol an......

Atomoxetine Decreases Mitochondrial Biogenesis, Fission and Fusion In Human Neuron-like Cells But Does Not Alter Antioxidant Defences

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; 81 (1)

Atomoxetine (ATX) is a presynaptic norepinephrine transporter (NET) inhibitor widely prescribed for attention-deficit/hyperactivity disorder (ADHD) du......

The SP/NK1R system promotes the proliferation of breast cancer cells through NF-?B-mediated inflammatory responses

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; ()

BackgroundNumerous molecules have been introduced to participate in the formation of breast cancer, the most common malignancy in women. Among them, n......

ER Stress Decreases Gene Expression Of Transmembrane Protein 117 Via Activation of PKR-like ER Kinase

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; 81 (3)

Stress response is an inherent mechanism in the endoplasmic reticulum (ER). The inducers of ER cause a specific cascade of reactions, leading to gene ......

Monoclonal Antibodies in Oncology: A Decade of Novel Options

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; ()

Several decades of research and clinical trials have conclusively provided proof of concept on the usefulness of monoclonal antibodies in the armament......

Synucleinopathies: Intrinsic and Extrinsic Factors

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; ()

a-Synucleinopathies are a group of neurodegenerative disorders characterized by alterations in a-synuclein (a-syn), a protein associated with membrane......

Does Oxidative Stress Along with Dysbiosis Participate in the Pathogenesis of Asthma in the Obese?

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; 81 (1)

The most important environmental factor that can play a key role in the development of asthma in the obese is overproduction of reactive oxygen specie......

Phospholipid scramblase 3: a latent mediator connecting mitochondria and heavy metal apoptosis

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; ()

Lead and mercury are the ubiquitous heavy metals triggering toxicity and initiating apoptosis in cells. Though the toxic effects of heavy metals on va......

Pancreatic β-Cell Apoptosis in Normoglycemic Rats is Due to Mitochondrial Translocation of p53-Induced by the Consumption of Sugar-Sweetened Beverages

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; ()

Overstimulation of pancreatic beta-cells can lead to dysfunction and death, prior to the clinical manifestations of type 2 diabetes (T2D). The excessi......

Impact of Interdependent Ca2+ and IP3 Dynamics On ATP Regulation in A Fibroblast Model

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; 81 (4)

The vital participation of Ca2+ in human organ functions such as muscular contractions, heartbeat, brain functionality, skeletal activity, etc, motiva......

An Atomic Level Investigation of Sodium Ions Regulating Agonist and Antagonist Binding in the Active Site of a Novel Target 5HT2BR Against Drug-Resistant Epilepsy

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; 81 (2)

The study investigates the movement of sodium ions inside the ligand-binding pocket of the class-A GPCR serotonin receptor (5HT(2B)R), a primary targe......

Spectral Phasor Analysis of Nile Red Identifies Membrane Microenvironment Changes in the Presence of Amyloid Peptides

期刊: CELL BIOCHEMISTRY AND BIOPHYSICS, 2023; 81 (1)

The interaction of protein and peptide amyloid oligomers with membranes is thought to be one of the mechanisms contributing to cellular toxicity. Howe......

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