期刊： SCIENCE IMMUNOLOGY, 2021; 6 (62)
A primary immune response is initiated in secondary lymphoid organs. Virtual memory CD8(+) T (T-VM) cells are antigen-inexperienced T cells of a centr......
期刊： SCIENCE IMMUNOLOGY, 2021; 6 (60)
Radiotherapy is an important anticancer treatment modality that activates innate and adaptive immune responses. When all-trans retinoic acid (RA) was ......
期刊： SCIENCE IMMUNOLOGY, 2021; 6 (57)
Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cel......
期刊： SCIENCE IMMUNOLOGY, 2021; 6 (58)
The functional diversification of dendritic cells (DCs) is a key step in establishing protective immune responses. Despite the importance of DC lineag......
期刊： SCIENCE IMMUNOLOGY, 2021; 6 (58)
Pharmacologically inhibiting nucleotide-binding domain and leucine-rich repeat-containing (NLR) family, pyrin domain-containing protein 3 (NLRP3) infl......
期刊： SCIENCE IMMUNOLOGY, 2021; 6 (61)
Conventional type 1 dendritic cells (cDC1s) are critical for antitumor immunity. They acquire antigens from dying tumor cells and cross-present them t......
期刊： SCIENCE IMMUNOLOGY, 2021; 6 (61)
The B7 family ligand HERV-H LTR-associating protein 2 (HHLA2) is an attractive target for cancer immunotherapy because of its coinhibitory function, o......
期刊： SCIENCE IMMUNOLOGY, 2021; 6 (59)
The inflammasome promotes inflammation-associated diseases, including cancer, and contributes to the radiation-induced tissue damage. However, the rol......
期刊： SCIENCE IMMUNOLOGY, 2020; 5 (44)
We investigated the molecular and cellular basis of severe combined immunodeficiency (SCID) in six patients with otofaciocervical syndrome type 2 who ......
期刊： SCIENCE IMMUNOLOGY, 2020; 5 (44)
Although mammalian secretory immunoglobulin A (sIgA) targets mucosal pathogens for elimination, its interaction with the microbiota also enables comme......
期刊： SCIENCE IMMUNOLOGY, 2020; 5 (44)
B cells undergo two types of genomic alterations to increase antibody diversity: introduction of point mutations into immunoglobulin heavy- and light-......
期刊： SCIENCE IMMUNOLOGY, 2020; 5 (46)
Intestinal mononuclear phagocytes (MPs) are composed of heterogeneous dendritic cell (DC) and macrophage subsets necessary for the initiation of immun......
期刊： SCIENCE IMMUNOLOGY, 2020; 5 (47)
Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed in COVID-19. However, it is unclear whether SARS-CoV-2 replicat......
期刊： SCIENCE IMMUNOLOGY, 2020; 5 (47)
Serological testing for SARS-CoV-2 has enormous potential to contribute to COVID-19 pandemic response efforts. However, the required performance chara......
期刊： SCIENCE IMMUNOLOGY, 2020; 5 (54)
Deficiency in interleukin-36R (IL-36R) antagonist caused by loss-of-function mutations in IL-36RN leads to DITRA (deficiency of IL-36 receptor antagon......
