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Potential impact of tuberculosis vaccines in China, South Africa, and India

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (564)

More effective tuberculosis vaccines are needed to help reach World Health Organization tuberculosis elimination goals. Insufficient evidence exists o......

Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (524)

Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic biomarker in many cancers. Here, we conducted a study to investigate t......

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (525)

The exocrine pancreas expresses the highest concentrations of fibroblast growth factor 21 (FGF21) in the body, where it maintains acinar cell proteost......

Plasma exosomal miR-375-3p regulates mitochondriadependent keratinocyte apoptosis by targeting XIAP in severe drug-induced skin reactions

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (574)

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug-induced cutaneous reactions characterized by keratinocyte apoptosi......

Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (574)

Precise form-fitting of prosthetic sockets is important for the comfort and well-being of persons with limb amputations. Capabilities for continuous m......

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (574)

Heat shock factor 1 (HSF1) is a cellular stress-protective transcription factor exploited by a wide range of cancers to drive proliferation, survival,......

Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (568)

Acute bacterial endocarditis is a rapid, difficult to manage, and frequently lethal disease. Potent antibiotics often cannot efficiently kill Staphylo......

Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (568)

Autoimmune diseases such as multiple sclerosis (MS) develop because of failed peripheral immune tolerance for a specific self-antigen (Ag). Numerous a......

Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (529)

Osteoclasts actively remodel both the mineral and proteinaceous components of bone during normal growth and development as well as pathologic states r......

Elevated plasma beta-hydroxybutyrate predicts adverse outcomes and disease progression in patients with arrhythmogenic cardiomyopathy

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (530)

Sudden death could be the first symptom of patients with arrhythmogenic cardiomyopathy (AC), a disease for which clinical indicators predicting advers......

Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (530)

Neonatal hyperbilirubinemia is a common clinical condition that can lead to brain encephalopathy, particularly when concurrent with acidosis due to in......

Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (531)

Epilepsy treatments for patients with mechanistic target of rapamycin (mTOR) disorders, such as tuberous sclerosis complex (TSC) or focal cortical dys......

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (531)

Long noncoding RNAs (lncRNAs) are emerging regulators of biological processes in the vessel wall; however, their role in atherosclerosis remains poorl......

Inhibition of the ALDH18A1-MYCN positive feedback loop attenuates MYCN-amplified neuroblastoma growth

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (531)

MYCN-amplified neuroblastoma (NB) is characterized by poor prognosis, and directly targeting MYCN has proven challenging. Here, we showed that aldehyd......

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

期刊: SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (570)

Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung histopathology often reveals fibrin-based blockages in the......

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