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Unique molecular characteristics of NAFLD-associated liver cancer accentuate beta-catenin/TNFRSF19-mediated immune evasion

期刊: JOURNAL OF HEPATOLOGY, 2022; 77 (2)

Background & Aims: The hepatic manifestation of the metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), can lead to the development of ......

JIF:9.655

Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis

期刊: JOURNAL OF HEPATOLOGY, 2022; 77 (2)

Background & Aims: The liver is a metabolically active organ and is also 'tolerogenic', exhibiting sophisticated mechanisms of immune regulation t......

JIF:9.655

Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma

期刊: JOURNAL OF HEPATOLOGY, 2022; 77 (2)

Background & Aims: The highly proliferative nature of hepato-cellular carcinoma (HCC) frequently results in a hypoxic intra-tumoural microenvironm......

JIF:9.655

PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy

期刊: JOURNAL OF HEPATOLOGY, 2022; 77 (1)

Background & Aims: Although the treatment of hepatocellular carcinoma (HCC) has been revolutionized by the advent of effective systemic therapies,......

JIF:9.655

Promises of microbiome-based therapies

期刊: JOURNAL OF HEPATOLOGY, 2022; 76 (6)

Humans harbour large quantities of microbes, including bacteria, fungi, viruses and archaea, in the gut. Patients with liver disease exhibit changes i......

JIF:9.655

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