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Comparing amyloid-beta plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease

期刊: ACTA NEUROPATHOLOGICA, 2021; 142 (4)

Pittsburgh compound B (PiB) radiotracer for positron emission tomography (PET) imaging can bind to different types of amyloid-beta plaques and blood v......

Multiple system atrophy-associated oligodendroglial protein p25 alpha stimulates formation of novel alpha-synuclein strain with enhanced neurodegenerative potential

期刊: ACTA NEUROPATHOLOGICA, 2021; 142 (1)

Pathology consisting of intracellular aggregates of alpha-Synuclein (alpha-Syn) spread through the nervous system in a variety of neurodegenerative di......

TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy

期刊: ACTA NEUROPATHOLOGICA, 2021; 142 (4)

The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TAR DNA-binding protein-43 (TDP-43) incl......

Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study

期刊: ACTA NEUROPATHOLOGICA, 2021; 141 (5)

Recent genomic studies have shed light on the biology and inter-tumoral heterogeneity underlying pineal parenchymal tumors, in particular pineoblastom......

Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis

期刊: ACTA NEUROPATHOLOGICA, 2021; 141 (2)

The deadly complication of brain metastasis (BM) is largely confined to a relatively narrow cross-section of systemic malignancies, suggesting a funda......

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

期刊: ACTA NEUROPATHOLOGICA, 2021; 141 (2)

The microtubule-associated protein tau has a critical role in Alzheimer's disease and other tauopathies. A proposed pathomechanism in the progression ......

Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates

期刊: ACTA NEUROPATHOLOGICA, 2020; 139 (4)

Corticobasal degeneration typically progresses gradually over 5-7 years from onset till death. Fulminant corticobasal degeneration cases with a rapidl......

Overlapping genetic architecture between Parkinson disease and melanoma

期刊: ACTA NEUROPATHOLOGICA, 2020; 139 (2)

Epidemiologic studies have reported inconsistent results regarding an association between Parkinson disease (PD) and cutaneous melanoma (melanoma). Id......

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

期刊: ACTA NEUROPATHOLOGICA, 2020; 140 (4)

Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune m......

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