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Salvianolic acid B inhalation solution enhances antifibrotic and anticoagulant effects in a rat model of pulmonary fibrosis

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 138 ()

The purpose of this study was to investigate the antifibrotic effect and anticoagulant ability of salvianolic acid B (SAB) inhalation solution on bleo......

Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 138 ()

Background: Curcumin exerts a suppressive effect in tumor growth by acting as a modulator of multiple molecular targets. Circular RNA hsa_circ_0007580......

An integrative strategy for discovery of functional compound combination from Traditional Chinese Medicine: Danhong Injection as a model

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 138 ()

Traditional Chinese Medicine formulas, which are usually considered exerting their holistic clinical benefits via multi-component, multi-target manner......

Randomised clinical trial: Efficacy and safety of Qing-Chang-Hua-Shi granules in a multicenter, randomized, and double-blind clinical trial of patients with moderately active ulcerative colitis

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 139 ()

Qing-Chang-Hua-Shi (QCHS) is a Chinese herbal formula, which is composed of 11 herbs. Studies have also shown that QCHS granules can alleviate colitis......

New insights in drug development for Alzheimer's disease based on microglia function

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 140 ()

One of the biggest challenges in drug development for Alzheimer's disease (AD) is how to effectively remove deposits of amyloid-beta (A13). Recently, ......

Advances of circular RNAs in thyroid cancer: An overview

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 140 ()

Circular RNA (circRNA) is a general term for a type of single-stranded RNAs, they are primarily generated via exon back-splice process in precursor mR......

Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 141 ()

Glioblastoma multiforme is one of the most deadly malignant tumors, with more than 10,000 cases recorded annually in the United States. Various clinic......

Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 141 ()

Ferroptosis is a type of regulated cell death driven by iron dependent accumulation of cellular reactive oxygen species (ROS) when glutathione (GSH)-d......

beta-patchoulene improves lipid metabolism to alleviate non-alcoholic fatty liver disease via activating AMPK signaling pathway

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 134 ()

Non-alcoholic fatty liver disease (NAFLD) has been a leading cause of chronic metabolic disease, seriously posing healthy burdens to the public, where......

919 syrup inhibits ROS-mediated leptin-induced anorexia by activating PPAR gamma and improves gut flora abnormalities

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 138 ()

Background: Women with postpartum psychiatric disorders are prone to severe anorexia. Clinical studies have revealed the efficacy of 919 syrup, a trad......

Antithrombotic and anticoagulant effects of a novel protein isolated from the venom of the Deinagkistrodon acutus snake

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 138 ()

The venom of the Deinagkistrodon acutus snake is composed of numerous bioactive proteins and peptides. In this study, we report the antithrombotic and......

A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 140 ()

Atopic dermatitis (AD) is considered a great challenge for human communities and imposes both physiological and mental burdens on patients. Natural pr......

Squalene nanoemulsion reinforces mucosal and immunological fingerprints following intravaginal delivery

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 141 ()

This study describes the assessment of mucosal adjuvant activity of a squalene-based nanoemulsion (SQ@NE ) following intravaginal delivery in mice. Af......

Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G(0) state arrest

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2021; 141 ()

Cancer recurrence poses a significant challenge. At the cellular level, recurrence takes place as a result of reactivation of dormant cancer cells res......

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