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Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (4)

Pdia4 has been characterized as a key protein that positively regulates beta-cell failure and diabetes via ROS regulation. Here, we investigated the f......

The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (6)

Antimicrobial peptides (AMPs) are major components of the innate immune defense. Accumulating evidence suggests that the antibacterial activity of man......

Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington's Disease

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (12)

BackgroundHuntington's Disease (HD) is a disorder that affects body movements. Altered glutamatergic innervation of the striatum is a major hallmark o......

Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (12)

A common perception in age-related neurodegenerative diseases posits that a decline in proteostasis is key to the accumulation of neuropathogenic prot......

Intrauterine botulinum toxin A administration promotes endometrial regeneration mediated by IGFBP3-dependent OPN proteolytic cleavage in thin endometrium

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (1)

Adequate endometrial growth is a critical factor for successful embryo implantation and pregnancy maintenance. We pre-viously reported the efficacy of......

Adaptive autophagy reprogramming in Schwann cells during peripheral demyelination

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (1)

The myelin sheath is an essential structure for the rapid transmission of electrical impulses through axons, and peripheral myelination is a well-prog......

Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (4)

Neurotrypsin (NT) is a neuronal trypsin-like serine protease whose mutations cause severe mental retardation in humans. NT is activated in vitro by He......

Tumor cell-intrinsic and tumor microenvironmental conditions co-determine signaling by the glycoimmune checkpoint receptor Siglec-7

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (6)

Tumors create an immunosuppressive tumor microenvironment by altering protein expression, but also by changing their glycosylation status, like altere......

Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (6)

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in adults with no curative treatment. Neurofilament (NF) level in pat......

Collagen VI sustains cell stemness and chemotherapy resistance in glioblastoma

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (8)

Microenvironmental factors are known fundamental regulators of the phenotype and aggressiveness of glioblastoma (GBM), the most lethal brain tumor, ch......

A duplex structure of SARM1 octamers stabilized by a new inhibitor

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (1)

In recent years, there has been growing interest in SARM1 as a potential breakthrough drug target for treating various pathologies of axon degeneratio......

Glyco-sulfo barcodes regulate chemokine receptor function

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (2)

Chemokine ligands and receptors regulate the directional migration of leukocytes. Post-translational modifications of chemokine receptors including O-......

Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (3)

Replication of viruses requires interaction with host cell factors and repression of innate immunity. Recent findings suggest that a subset of intrace......

DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells via the mTOR signaling pathway

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (7)

DIS3L2 degrades different types of RNAs in an exosome-independent manner including mRNAs and several types of non-coding RNAs. DIS3L2-mediated degrada......

Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (8)

AimsArrhythmogenic cardiomyopathy (AC) is a severe heart disease predisposing to ventricular arrhythmias and sudden cardiac death caused by mutations ......

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