筛选条件 共查询到500条结果
排序方式
28-day repeated dose toxicity and toxicokinetics study on new melatonergic antidepressant GW117 in beagle dogs

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (4)

GW117 is new melatonergic antidepressant being developed to show better antidepressant action than agomelatine. The purpose of this study was to evalu......

Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (6)

Curcumin, one of the three principal curcuminoids found within turmeric rhizomes, has long been associated with numerous physiologically beneficial ef......

Effects of plasticizer diisobutyl adipate on the Japanese medaka (Oryzias latipes) endocrine system

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (7)

Plasticizer pollution of the water environment is one of the world's most serious environmental issues. Phthalate plasticizers can disrupt endocrine f......

Protocatechuic acid ameliorates lipopolysaccharide-induced kidney damage in mice via downregulation of TLR-4-mediated IKBKB/NF-?B and MAPK/Erk signaling pathways

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (8)

Acute kidney injury (AKI) is a very critical cause of death in the whole world. Lipopolysaccharide (LPS) induces kidney damage by activating various d......

Exposure of quantum dots in the nervous system: Central nervous system risks and the blood-brain barrier interface

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; ()

Quantum dots currently possess significant importance in the field of biomedical science. Upon introduction into the body, quantum dots exhibit a tend......

Internalization and cytotoxicity of polystyrene microplastics in human umbilical vein endothelial cells

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (2)

Ubiquitous micro(nano)plastics (MNPs) are emerging environmental pollutants, which pose a potential threat to human health. When MNPs enter the blood ......

Neurodevelopmental toxicity induced by airborne particulate matter

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (1)

Airborne particulate matter (PM), the primary component associated with health risks in air pollution, can negatively impact human health. Studies hav......

Cytogenotoxicity assessment of 3-(3,4-dihydroxyphenyl)-7,8-dihydroxycoumarin on HepG2/C3A cells and leukocytes

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (2)

3-(3,4-Dihydroxyphenyl)-7,8-dihydroxycoumarin is a newly synthesized coumarin derivative with a potent antioxidant effect. The aim of the present stud......

Reprotoxicity induced by acute exposure to aqueous tuber extract of Peruvian Maca (Lepidium meyenii Walp.) in Caenorhabditis elegans

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (7)

Maca (Lepidium meyenii Walp.) has been used in folk medicine to treat fertility disturbances, a claim that has been evidenced in some studies. However......

5-Hydroxymethylfurfural multimers induce pseudo-allergic reaction through FcεRI at high doses

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (8)

Under acidic and high temperature conditions, 5-hydroxymethylfurfural (5-HMF) converted from sugar further produces dimers (Compound II) and trimers (......

Benzo[b]fluoranthene induced oxidative stress and apoptosis in human airway epithelial cells via mitochondrial disruption

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (7)

Benzo[b]fluoranthene (BbF) is a common constituent of polycyclic aromatic hydrocarbons (PAHs). While numerous studies revealed adverse effects of PAHs......

Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (8)

Inorganic arsenic (iAs) has been a human health concern and is associated with intestinal malignancies. However, the molecular mechanisms of the iAs-i......

Oral exposure to citrinin significantly exacerbates the pathophysiology of a mouse model of imiquimod-induced psoriasis via direct activation of dendritic cell

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (9)

Citrinin, a mycotoxin produced by Penicillium citrinum and Penicillium verrucosum, mainly contaminates cereals. The aim of study was to investigate th......

Neurodevelopmental toxicity of bisphenol AF in zebrafish larvae and the protective effects of curcumin

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; 43 (12)

Bisphenol AF (BPAF) is one of the most commonly used alternatives of bisphenol A in the plastics industry. The effects of BPAF on nervous development ......

Allocholic acid protects against α-naphthylisothiocyanate-induced cholestasis in mice by ameliorating disordered bile acid homeostasis

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2023; ()

Cholestasis is a pathological condition characterized by disruptions in bile flow, leading to the accumulation of bile acids (BAs) in hepatocytes. All......

共500条页码: 1/34页15条/页