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Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Peripheral nerve injury (PNI) often results in spontaneous motor recovery; however, how disrupted cerebellar circuitry affects PNI-associated motor re......

JIF:8.6

Biomechanically and biochemically functional scaffold for recruitment of endogenous stem cells to promote tendon regeneration

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Tendon regeneration highly relies on biomechanical and biochemical cues in the repair microenvironment. Herein, we combined the decellularized bovine ......

JIF:8.6

Mussel-inspired multifunctional surface through promoting osteogenesis and inhibiting osteoclastogenesis to facilitate bone regeneration

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Osteogenesis and osteoclastogenesis are closely associated during the bone regeneration process. The development of multifunctional bone repair scaffo......

JIF:8.6

Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Duchenne muscular dystrophy (DMD) is a progressive genetic myopathy that leads to heart failure from dilated cardiomyopathy by early adulthood. Recent......

JIF:8.6

Tubular epithelial cells-derived small extracellular vesicle-VEGF-A promotes peritubular capillary repair in ischemic kidney injury

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Peritubular capillaries (PTCs) are closely related to renal tubules in structure and function, and both are pivotal regulators in the development and ......

JIF:8.6

DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

In cases of extensive liver injury, biliary epithelial cells (BECs) dedifferentiate into bipotential progenitor cells (BPPCs), then redifferentiate in......

JIF:8.6

FoxO3 restricts liver regeneration by suppressing the proliferation of hepatocytes

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Upon injury, the liver is capable of substantial regeneration from the original tissue until an appropriate functional size. The underlying mechanisms......

JIF:8.6

Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Osteoarthritis (OA) is the leading cause of disability worldwide. Considerable progress has been made using stem-cell-derived therapy. increasing evid......

JIF:8.6

Clinically relevant small-molecule promotes nerve repair and visual function recovery

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Adult mammalian injured axons regenerate over short-distance in the peripheral nervous system (PNS) while the axons in the central nervous system (CNS......

JIF:8.6

Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Mammalian sensory hair cells (HCs) have limited capacity for regeneration, which leads to permanent hearing loss after HC death. Here, we used in vitr......

JIF:8.6

Bi-potential hPSC-derived Mullerian duct-like cells for full-thickness and functional endometrium regeneration

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Stem cell-based tissue regeneration strategies are promising treatments for severe endometrial injuries. However, there are few appropriate seed cells......

JIF:8.6

Multi-biofunctional graphene oxide-enhanced poly-L-lactic acid composite nanofiber scaffolds for ovarian function recovery of transplanted-tissue

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

In this study, we successfully constructed the new graphene oxide/poly-L-lactic acid (GO/PLLA) nanofiber scaffolds with a hydrophilic surface and poro......

JIF:8.6

Rapid induction and long-term self-renewal of neural crest-derived ectodermal chondrogenic cells from hPSCs

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Articular cartilage is highly specific and has limited capacity for regeneration if damaged. Human pluripotent stem cells (hPSCs) have the potential t......

JIF:8.6

Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration

期刊: NPJ REGENERATIVE MEDICINE, 2022; 7 (1)

Reconstruction of complex cartilage defects has remained a great challenge for tissue engineering due to the lack of stem cells and chronic inflammati......

JIF:8.6

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