期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (6)
BRCA2 controls RAD51 recombinase during homologous DNA recombination (HDR) through eight evolutionarily conserved BRC repeats, which individually enga......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (6)
Phenotypic screening for bioactive small molecules is typically combined with affinity-based chemical proteomics to uncover the respective molecular t......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (5)
As a typical member of intrinsically disordered proteins (IDPs), HMGA1a carries many post-translational modifications (PTMs). To study the undefined f......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (5)
Wnt signaling plays a central role in tissue maintenance and cancer. Wnt activates downstream genes through beta-catenin, which interacts with TCF/LEF......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (6)
The COVID-19 pandemic has been disastrous to society and effective drugs are urgently needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (S......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (2)
The accumulation of alpha-synuclein amyloid fibrils in the brain is linked to Parkinson's disease and other synucleinopathies. The intermediate specie......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (5)
2-Aminovinyl-cysteine (AviCys) is a thioether amino acid shared by a variety of ribosomally synthesized and posttranslationally modified peptides (RiP......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (6)
Emerging evidence indicates the involvement of O-GlcNAc modification in placental development and pregnant health through mechanisms that are not well......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (5)
We previously tested HER2-targeted antibody-drug conjugates (ADCs) in immunocompromised (SCID) mice, precluding evaluation of host immunity, impact on......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (5)
Tumor suppressor genes represent a major class of oncogenic drivers. However, direct targeting of loss-offunction tumor suppressors remains challengin......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (6)
Ferroptosis is a type of nonapoptotic cell death driven by lipid peroxidation. Here, we show a key role of MGST1 in inhibiting ferroptosis in cell cul......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (1)
Chimeric antigen receptor (CAR)-T-based therapeutics are a breakthrough in cancer treatment; however, they are hampered by constitutive activation, wh......
期刊： CELL CHEMICAL BIOLOGY, 2021; 28 (3)
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity ("nuisance compounds'') are routinely encountered in cellular assay......
期刊： CELL CHEMICAL BIOLOGY, 2020; 27 (4)
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular process capable of degr.:.:!ing various biological molecul......
期刊： CELL CHEMICAL BIOLOGY, 2020; 27 (5)
In this study, we identify the natural product gambogic acid as well as structurally related synthetic xanthones as first-in-class covalent inhibitors......
