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Autophagy-Dependent Ferroptosis: Machinery and Regulation

期刊: CELL CHEMICAL BIOLOGY, 2020; 27 (4)

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular process capable of degr.:.:!ing various biological molecul......

Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex

期刊: CELL CHEMICAL BIOLOGY, 2020; 27 (5)

In this study, we identify the natural product gambogic acid as well as structurally related synthetic xanthones as first-in-class covalent inhibitors......

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