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Fibroblast growth factor 2 (FGF2) ameliorates the coagulation abnormalities in sepsis

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 460 ()

Background: Sepsis is defined as a life-threatening organ dysfunction caused by dysregulation of the host response to infection. There is still a lack......

The inhibitory effect of escitalopram on mouse detrusor contractility: The role of L-type calcium channels

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 461 ()

Selective serotonin reuptake inhibitors (SSRIs) are associated with urinary problems attributed to their central effects. ESC is a preferred SSRI and ......

Applications of promiscuity of FDA-approved kinase inhibitors in drug repositioning and toxicity

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 465 ()

Promiscuity of therapeutics has important implications in treatment and toxicity. So far, a comprehensive un-derstanding of promiscuity related to kin......

An inclusive outlook on the fate and persistence of pesticides in the environment and integrated eco-technologies for their degradation

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 466 ()

Intensive and inefficient exploitation of pesticides through modernized agricultural practices has caused severe pesticide contamination problems to t......

Suppression of SIRT1/FXR signaling pathway contributes to oleanolic acid-induced liver injury

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 467 ()

Oleanolic acid (OA) is a pentacyclic triterpenoid compound used clinically for acute and chronic hepatitis. However, high dose or long-term use of OA ......

Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 474 ()

Endocrine disrupting compounds are the chemicals which mimics the natural endocrine hormones and bind to the receptors made for the hormones. Upon bin......

Linking chemicals, genes and morphological perturbations to diseases

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 461 ()

The progress in image-based high-content screening technology has facilitated high-throughput phenotypic profiling notably the quantification of cell ......

The comparative analysis of gastrointestinal toxicity of azithromycin and 3′-decladinosyl azithromycin on zebrafish larvae

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 469 ()

The most commonly reported side effect of azithromycin is gastrointestinal (GI) disorders, and the main acid degradation product is 3'-Decladinosyl az......

Exposure to metam sodium-based pesticide impaired cognitive performances in adult mice: Involvement of oxidative damage and glial activation

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 477 ()

Cognitive integrity is a critical aspect of neurological function, and a decline in cognitive function is a hallmark of neurotoxicity. Oxidative stres......

Pentachlorophenol exposure induced neurotoxicity by disrupting citrulline metabolism in larvae and adult zebrafish

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 478 ()

Pentachlorophenol (PCP) is a ubiquitous environmental toxicant with various adverse effects. Although its neurotoxicity has been reported, the underly......

Kaempferol ameliorates pulmonary vascular remodeling in chronic hypoxia-induced pulmonary hypertension rats via regulating Akt-GSK38-cyclin axis

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 466 ()

Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) is considered a major contributor to elevated pulmonary vascular resistance a......

Platelet-to-lymphocyte ratio predicts the duration of glucocorticoid therapy in the treatment of cutaneous adverse drug reactions

期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023; 468 ()

Background: Glucocorticoid (GC) remains the mainstay of treatment for cutaneous adverse drug reactions (cADRs) but has been associated with side effec......

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