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The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC

期刊: MOLECULAR CANCER, 2021; 20 (1)

Background Recent studies have revealed that circular RNAs (circRNAs) play significant roles in the occurrence and development of many kinds of cancer......

A novel NF-kappa B regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation

期刊: MOLECULAR CANCER, 2021; 20 (1)

Background: Constitutive activation of nuclear factor-kappa B (NF-kappa B) signaling plays a key role in the development and progression of colorectal......

The role and application of small extracellular vesicles in gastric cancer

期刊: MOLECULAR CANCER, 2021; 20 (1)

Gastric cancer (GC) is a common tumour that affects humans worldwide, is highly malignant and has a poor prognosis. Small extracellular vesicles (sEVs......

The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy

期刊: MOLECULAR CANCER, 2021; 20 (1)

Cancer immunotherapy has recently shown promising antitumor effects in various types of tumors. Among all immune checkpoints, the PD-1/PD-L1 pathway p......

CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability

期刊: MOLECULAR CANCER, 2021; 20 (1)

Background Circular RNAs (circRNAs) play important roles in cancer development and progression. The purpose of this study is to identify aberrantly ex......

Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-kappa B/bone remodeling factors signaling

期刊: MOLECULAR CANCER, 2021; 20 (1)

Background: Breast cancer (BC) has a marked tendency to spread to the bone, resulting in significant skeletal complications and mortality. Recently, c......

Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications

期刊: MOLECULAR CANCER, 2021; 20 (1)

Exosomes are a subpopulation of the tumour microenvironment (TME) that transmit various biological molecules to promote intercellular communication. E......

Using single-cell sequencing technology to detect circulating tumor cells in solid tumors

期刊: MOLECULAR CANCER, 2021; 20 (1)

Circulating tumor cells are tumor cells with high vitality and high metastatic potential that invade and shed into the peripheral blood from primary s......

CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity

期刊: MOLECULAR CANCER, 2021; 20 (1)

Background Cirrhosis is a recognized risk factor for developing hepatocellular carcinoma (HCC). Few studies have reported the expression profile of ci......

GM-CSF mediates immune evasion via upregulation of PD-L1 expression in extranodal natural killer/T cell lymphoma

期刊: MOLECULAR CANCER, 2021; 20 (1)

Background Granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine that is used as an immunopotentiator for anti-tumor therapies in re......

KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1

期刊: MOLECULAR CANCER, 2021; 20 (1)

Background KDM6A, a histone demethylase, is frequently mutated in bladder cancer (BCa). However, the role and detailed molecular mechanism of KDM6A in......

Tumor-associated exosomes promote lung cancer metastasis through multiple mechanisms

期刊: MOLECULAR CANCER, 2021; 20 (1)

As an important medium of intercellular communication, exosomes play an important role in information transmission between tumor cells and their micro......

CircPTPRA blocks the recognition of RNA N-6-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression

期刊: MOLECULAR CANCER, 2021; 20 (1)

Background Circular RNAs (circRNAs) have been found to have significant impacts on bladder cancer (BC) progression through various mechanisms. In this......

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