期刊: CLINICAL SCIENCE, 2021; 135 (2)
Brain renin-angiotensin system (RAS) activation is thought to mediate deoxycorticosterone acetate (DOCA)-salt hypertension, an animal model for human ......
期刊: CLINICAL SCIENCE, 2021; 135 (12)
Chronic hepatitis B virus (HBV) infection is a significant public health burden worldwide. HBV covalently closed circular DNA (cccDNA) organized as a ......
期刊: CLINICAL SCIENCE, 2021; 135 (6)
Until now, renin-angiotensin system (RAS) hyperactivity was largely thought to result from angiotensin II (Ang II)-dependent stimulation of the Ang II......
期刊: CLINICAL SCIENCE, 2021; 135 (2)
Hypertensive nephropathy (HN) is a common cause of end-stage renal disease with renal fibrosis; chronic kidney disease is associated with elevated ser......
期刊: CLINICAL SCIENCE, 2021; 135 (15)
Although accelerated cellular senescence is closely related to the progression of chronic kidney disease (CKD) and renal fibrosis, the underlying mech......
期刊: CLINICAL SCIENCE, 2021; 135 (4)
Tumor microenvironment (TME) exerts key roles in pancreatic ductal adenocarcinoma (PDAC) development. However, the factors regulating the cross-talk b......
期刊: CLINICAL SCIENCE, 2021; 135 (7)
Exercise training improves muscle fitness in many aspects, including induction of mitochondrial biogenesis and maintenance of mitochondrial dynamics. ......
期刊: CLINICAL SCIENCE, 2021; 135 (14)
Epigenetic dysregulation has long been identified as a key driver of leukemogenesis in acute myeloid leukemia (AML). However, epigenetic drugs such as......
期刊: CLINICAL SCIENCE, 2021; 135 (14)
Recent studies reveal that bile acid metabolite composition and its metabolism are changed in metabolic disorders, such as obesity, type 2 diabetes an......
期刊: CLINICAL SCIENCE, 2021; 135 (4)
The high disability, mortality and morbidity of diabetic ulcers make it urgent to explore effective strategies for diabetic wound repair. TrxR1 plays ......
期刊: CLINICAL SCIENCE, 2021; 135 (3)
Kallistatin is a multiple functional serine protease inhibitor that protects against vascular injury, organ damage and tumor progression. Kallistatin ......
期刊: CLINICAL SCIENCE, 2021; 135 (7)
Liver diseases present a significant public health burden worldwide. Although the mechanisms of liver diseases are complex, it is generally accepted t......
期刊: CLINICAL SCIENCE, 2021; 135 (15)
In the present study, we tested the hypothesis that there are significant sex differences in angiotensin II (Ang II)-induced hypertension and kidney i......
期刊: CLINICAL SCIENCE, 2021; 135 (6)
The endothelial-to-mesenchymal transition (EndMT) is a critical process that occurs during the development of the outflow tract (OFT). Malformations o......
期刊: CLINICAL SCIENCE, 2021; 135 (11)
We aimed to investigate the role of cMet agonistic antibody (cMet Ab) in preventing kidney fibrosis during acute kidney injury (AKI) to chronic kidney......