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Conversion of Classical and 11-Oxygenated Androgens by Insulin-Induced AKR1C3 in a Model of Human PCOS Adipocytes

期刊: ENDOCRINOLOGY, 2022; 163 (7)

Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women. A common symptom of PCOS is hyperandrogenism (AE); however, the source......

JIF:3.988

Excess Growth Hormone Alters the Male Mouse Gut Microbiome in an Age-dependent Manner

期刊: ENDOCRINOLOGY, 2022; 163 (7)

The gut microbiome has an important role in host development, metabolism, growth, and aging. Recent research points toward potential crosstalk between......

JIF:3.988

Streptozotocin-induced Diabetes Represses Hepatic CYP2R1 Expression but Induces Vitamin D 25-Hydroxylation in Male Mice

期刊: ENDOCRINOLOGY, 2022; 163 (7)

Vitamin D deficiency [ie, low plasma 25-hydroxyvitamin D (25-OH-D)] associates with the prevalence of metabolic diseases including type 1 diabetes; ho......

JIF:3.988

Metabolic Regulation of Hormone Secretion in Beta-Cells and Alpha-Cells of Female Mice: Fundamental Differences

期刊: ENDOCRINOLOGY, 2022; 163 (10)

It is unclear whether the secretion of glucagon is regulated by an alpha-cell-intrinsic mechanism and whether signal recognition by the mitochondrial ......

JIF:3.988

Gut and Breast Microbiota as Endocrine Regulators of Hormone Receptor-positive Breast Cancer Risk and Therapy Response

期刊: ENDOCRINOLOGY, 2022; 164 (1)

Despite advances in treatment strategies, breast cancer (BC) remains one of the most prevalent cancers worldwide. Recent studies implicate the gut mic......

JIF:3.988

Downregulation of Dihydrotestosterone and Estradiol Levels by HEXIM1

期刊: ENDOCRINOLOGY, 2022; 163 (1)

We have previously reported that hexamethylene bis-acetamide inducible protein 1 (HEXIM1) inhibits the activity of ligand-bound estrogen receptor alph......

JIF:3.988

Expression Profile of the GLP-1 Receptor in the Gastrointestinal Tract and Pancreas in Adult Female Mice

期刊: ENDOCRINOLOGY, 2022; 163 (1)

Therapies based on glucagon-like peptide-1 receptor (GLP-1R) agonism are highly effective in treating type 2 diabetes and obesity, but the localizatio......

JIF:3.988

Metabolic Homeostasis: It's All in the Timing

期刊: ENDOCRINOLOGY, 2022; 163 (1)

Cross-talk between peripheral tissues is essential to ensure the coordination of nutrient intake with disposition during the feeding period, thereby p......

JIF:3.988

Exploiting Mouse Models to Recapitulate Clinical Tumor Dormancy and Recurrence in Breast Cancer

期刊: ENDOCRINOLOGY, 2022; 163 (6)

Breast cancer recurrence and metastasis from activated dormant tumors remain the leading causes in disease morbidity. Women with estrogen receptor-pos......

JIF:3.988

Dual-Acting Peptides Target EZH2 and AR: A New Paradigm for Effective Treatment of Castration-Resistant Prostate Cancer

期刊: ENDOCRINOLOGY, 2022; 164 (1)

Prostate cancer starts as a treatable hormone-dependent disease, but often ends in a drug-resistant form called castration-resistant prostate cancer (......

JIF:3.988

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