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SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background SLCO4A1-AS1 was found to be upregulated in several cancer types, including colorectal cancer (CRC). However, the detailed roles of SLCO4A1-......

JIF:7.628

Early innate immune response triggered by the human respiratory syncytial virus and its regulation by ubiquitination/deubiquitination processes

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

The human respiratory syncytial virus (HRSV) causes severe lower respiratory tract infections in infants and the elderly. An exuberant inadequate immu......

JIF:7.628

Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background: Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement of resistance to temozolomide (TMZ). Particularly, the role......

JIF:7.628

DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for mainta......

JIF:7.628

Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background Living organisms are continuously exposed to multiple internal and external stimuli which may influence their emotional, psychological, and......

JIF:7.628

Delivering genes with human immunodeficiency virus-derived vehicles: still state-of-the-art after 25 years

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Viruses are naturally endowed with the capacity to transfer genetic material between cells. Following early skepticism, engineered viruses have been u......

JIF:7.628

Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background Aberrant DNA repair pathways contribute to malignant transformation or disease progression and the acquisition of drug resistance in multip......

JIF:7.628

Interleukin-20 is involved in dry eye disease and is a potential therapeutic target

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background: Dry eye disease (DED) is a common disease in ophthalmology, affecting millions of people worldwide. Recent studies have shown that inflamm......

JIF:7.628

Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background: Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The......

JIF:7.628

Distribution of papG alleles among uropathogenic Escherichia coli from reproductive age women

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background Extraintestinal Escherichia coli (E. coli) causing urinary tract infections (UTIs), and often referred to as uropathogenic E. coli (UPEC), ......

JIF:7.628

Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

The major concept of oxidative stress is an excess elevated level of reactive oxygen species (ROS) which are generated from vigorous metabolism and co......

JIF:7.628

COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Coronavirus Disease 2019 (COVID-19) has been the most severe public health challenge in this century. Two years after its emergence, the rapid develop......

JIF:7.628

Short open reading frames (sORFs) and microproteins: an update on their identification and validation measures

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

A short open reading frame (sORFs) constitutes <= 300 bases, encoding a microprotein or sORF-encoded protein (SEP) which comprises <= 100 amino ......

JIF:7.628

HrpA anchors meningococci to the dynein motor and affects the balance between apoptosis and pyroptosis

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background In Neisseria meningitidis the HrpA/HrpB two-partner secretion system (TPS) was implicated in diverse functions including meningococcal comp......

JIF:7.628

Recent advances in conventional and unconventional vesicular secretion pathways in the tumor microenvironment

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

All cells in the changing tumor microenvironment (TME) need a class of checkpoints to regulate the balance among exocytosis, endocytosis, recycling an......

JIF:7.628

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