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A DNA methylation signature for the prediction of tumour recurrence in stage II colorectal cancer

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (9)

BackgroundA major challenge in stage II colorectal carcinoma is to identify patients with increased risk of recurrence. Biomarkers that distinguish pa......

Socio-economic and ethnic disparities in childhood cancer survival, Yorkshire, UK

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (9)

Background: Establishing the existence of health inequalities remains a high research and policy agenda item in the United Kingdom. We describe ethnic......

The role of cytoreductive nephrectomy and systemic therapy in the management of tumour thrombus in patients with metastatic renal cell carcinoma

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (10)

BackgroundOutcomes for patients with metastatic renal cell carcinoma (mRCC) and tumour thrombus remain poor. Recent data suggest limited role for cyto......

Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (10)

Background One-third of cancers activate endogenous synthesis of serine/glycine, and can become addicted to this pathway to sustain proliferation and ......

Detection of circulating cell-free HPV DNA of 13 HPV types for patients with cervical cancer as potential biomarker to monitor therapy response and to detect relapse

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (11)

BackgroundHPV-related cervical cancer (CC) is the fourth most frequent cancer in women worldwide. Cell-free tumour DNA is a potent biomarker to detect......

Immunogenic hypofractionated radiotherapy sensitising head and neck squamous cell carcinoma to anti-PD-L1 therapy in MDSC-dependent manner

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (11)

Background: Enhancing the response rate of immunotherapy will aid in the success of cancer treatment. Here, we aimed to explore the combined effect of......

A multimodal imaging study to highlight elastin-derived peptide pro-tumoral effect in a pancreatic xenograft model

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (11)

BackgroundPancreatic ductal adenocarcinoma (PDAC) is highly malignant with a very poor prognosis due to its silent development and metastatic profile ......

Development and validation of a multivariable model for prediction of malignant transformation and recurrence of oral epithelial dysplasia

期刊: BRITISH JOURNAL OF CANCER, 2023; 129 (10)

Background: Oral epithelial dysplasia (OED) is the precursor to oral squamous cell carcinoma which is amongst the top ten cancers worldwide. Prognosti......

Biopsy-free AI-aided precision MRI assessment in prediction of prostate cancer biochemical recurrence

期刊: BRITISH JOURNAL OF CANCER, 2023; 129 (10)

BACKGROUND: To investigate the predictive ability of high-throughput MRI with deep survival networks for biochemical recurrence (BCR) of prostate canc......

Hepatitis B virus X protein promotes MAN1B1 expression by enhancing stability of GRP78 via TRIM25 to facilitate hepatocarcinogenesis

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (6)

BackgroundGRP78 has been implicated in hepatocarcinogenesis. However, the clinical relevance, biological functions and related regulatory mechanisms o......

Proactive breast cancer risk assessment in primary care: a review based on the principles of screening

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (9)

In the UK, the National Institute for Health and Care Excellence (NICE) recommends that women at moderate or high risk of breast cancer be offered ris......

The oncogenic roles and clinical implications of YAP/TAZ in breast cancer

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (9)

Breast cancer (BC) is the most commonly diagnosed form of cancer and a leading cause of cancer-related deaths among women worldwide. Yes-associated pr......

Tumour infiltrating lymphocytes and survival after adjuvant chemotherapy in patients with gastric cancer: post-hoc analysis of the CLASSIC trial

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (12)

BackgroundOnly a subset of gastric cancer (GC) patients with stage II-III benefits from chemotherapy after surgery. Tumour infiltrating lymphocytes pe......

Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma

期刊: BRITISH JOURNAL OF CANCER, 2023; 128 (12)

Background: Driver alterations may represent novel candidates for driver gene-guided therapy; however, intrahepatic cholangiocarcinoma (ICC) with mult......

Maternal and childhood medical history and the risk of childhood brain tumours: a case-control study in Ontario, Canada

期刊: BRITISH JOURNAL OF CANCER, 2023; 129 (2)

BackgroundStudies to date have yielded inconclusive results as to whether maternal medical history during pregnancy, and a child's early-life medical ......

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