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Integrative microbiomics in bronchiectasis exacerbations

期刊: NATURE MEDICINE, 2021; 27 (4)

Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection. We present an approach to the multi-bi......

How kindness can be contagious in healthcare

期刊: NATURE MEDICINE, 2021; 27 (7)

Pay-it-forward programs, whereby someone receives a gift or free service and then gives a gift to another person in return, have expanded during the C......

Safety and immunogenicity of the SARS-CoV-2 BNT162b1 mRNA vaccine in younger and older Chinese adults: a randomized, placebo-controlled, double-blind phase 1 study

期刊: NATURE MEDICINE, 2021; 27 (6)

An effective vaccine is needed to end the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Here, we assess the preliminary safet......

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

期刊: NATURE MEDICINE, 2021; 27 (3)

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS......

Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial

期刊: NATURE MEDICINE, 2021; 27 (7)

Fecal microbial transplantation (FMT) from lean donors to patients with obesity has been associated with metabolic benefits, yet results so far have b......

A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer

期刊: NATURE MEDICINE, 2021; 27 (5)

Transcriptomic and proteomic profiling of breast cancer biopsies identifies baseline features of the tumor immune microenvironment associated with T c......

The Tuberculosis Drug Accelerator at year 10: what have we learned?

期刊: NATURE MEDICINE, 2021; 27 (8)

The Tuberculosis Drug Accelerator, an experiment designed to facilitate collaboration in tuberculosis drug discovery by breaking down barriers among c......

Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

期刊: NATURE MEDICINE, ; ()

We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United ......

Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma

期刊: NATURE MEDICINE, ; ()

B cell maturation antigen (BCMA) is a target for various immunotherapies and a biomarker for tumor load in multiple myeloma (MM). We report a case of ......

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

期刊: NATURE MEDICINE, ; ()

A comprehensive analysis of antibody neutralization activity against a panel of authentic isolates and chimeric SARS-CoV-2 variants shows markedly dim......

Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson's disease

期刊: NATURE MEDICINE, 2021; 27 (3)

Animal studies implicate meningeal lymphatic dysfunction in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease and Parkinson's......

A perfusable, multifunctional epicardial device improves cardiac function and tissue repair

期刊: NATURE MEDICINE, 2021; 27 (3)

Despite advances in technologies for cardiac repair after myocardial infarction (MI), new integrated therapeutic approaches still need to be developed......

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