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Tumor-derived exosomal microRNA-7-5p enhanced by verbascoside inhibits biological behaviors of glioblastoma in vitro and in vivo

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 20 ()

Verbascoside (VB), a glycosylated phenylpropane compound, has been widely used in traditional medicine showing anti-inflammatory and anti-tumor effect......

Tumor immune microenvironment-based classifications of bladder cancer for enhancing the response rate of immunotherapy

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 20 ()

Immunotherapy is a potential way to save the lives of patients with bladder cancer, but it only benefits approximately 20% of them. A total of 4,028 b......

Knockdown of the DJ-1 (PARK7) gene sensitizes pancreatic cancer to erlotinib inhibition

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 20 ()

The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib, in combination with gemcitabine, has been shown to be a promising the......

Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 21 ()

Oncolytic viruses (OVs) represent promising therapeutic agents for cancer therapy by selective oncolysis and induction of anti-tumor immunity. OVs can......

miR-19a/b promote EMT and proliferation in glioma cells via SEPT7-AKT-NF-kappa B pathway

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 20 ()

miR-19a/b belong to the miR-17-92 family. We have demonstrated previously that miR-19a/b are overexpressed in glioma and glioma cell lines. However, t......

circBANP promotes colorectal cancer growth and metastasis via sponging let-7d-5p to modulate HMGA1/Wnt/beta-catenin signaling

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 21 ()

Colorectal cancer (CRC) is one of the most common and deadly cancers, and the incidence of CRC is on the rise. Due to the lack of early diagnosis meth......

Upregulation of deubiquitinase USP7 by transcription factor FOXO6 promotes EC progression via targeting the JMJD3/CLU axis

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 20 ()

Esophageal carcinoma (EC) is recognized as one of the most frequently occurring malignancies worldwide, and its high morbidity rate motivates efforts ......

The lncRNADLGAP1-AS1/miR-149-5p/TGFB2 axis contributes to colorectal cancer progression and 5-FU resistance by regulating smad2 pathway

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 20 ()

Colorectal carcinoma (CRC) ranks as the third most common malignancy. Long non-coding RNA DLGAP1-AS1 was reported to be dysregulated and to play a piv......

Association of IDH mutation and 1p19q co-deletion with tumor immune microenvironment in lower-grade glioma

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 21 ()

Although the successful clinical trials of immunotherapy show promising strategies for many cancers, its application in glioma has lagged in compariso......

Circular RNAs act as regulators of autophagy in cancer

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 21 ()

Circular RNAs (circRNAs) are a large class of noncoding RNAs that are emerging as critical regulators of various cellular processes that are involved ......

Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 20 ()

The potency of cancer vaccines is often compromised by a variety of immunoinhibitory mechanisms, including stimulation of the programmed cell death pr......

Quantitative proteomics characterization of cancer biomarkers and treatment

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 21 ()

Cancer accounted for 16% of all death worldwide in 2018. Significant progress has been made in understanding tumor occurrence, progression, diagnosis,......

LINC00461 facilitates HNSCC development and reduces chemosensitivity by impairing miR-195-mediated inhibition of HOXA10

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 21 ()

Homeobox A10 (HOXA10) has been regarded to serve as an oncogene in head and neck squamous cell carcinoma (HNSCC). This study was intended to explore t......

Inhibition of tumor invasion and metastasis by targeting TGF-beta-Smad-MMP2 pathway with Asiatic acid and Naringenin

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 20 ()

Transforming growth factor beta (TGF-beta) has been shown to promote tumor invasion and metastasis by activating the matrix metalloproteinases (MMPs);......

Preclinical evaluation of a novel antibody-drug conjugate targeting DR5 for lymphoblastic leukemia therapy

期刊: MOLECULAR THERAPY-ONCOLYTICS, 2021; 21 ()

Acute lymphoblastic leukemia (ALL) is an aggressive hemato-logical neoplasm resulting from immature lymphoid precursors. An antibody-drug conjugate (A......

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