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Estrogen enhanced the expression of IL-17 by tissue-resident memory gamma delta T cells from uterus via interferon regulatory factor 4

期刊: FASEB JOURNAL, 2022; 36 (2)

Tissue-resident memory gamma delta T cells at mucosal and epithelial sites play an important role for pathogen clearance, immunosurveillance, and part......

JIF:4.336

Down-regulated TINAGL1 in fibroblasts impairs wound healing in diabetes

期刊: FASEB JOURNAL, 2022; 36 (3)

Matricellular proteins, a group of extracellular matrix (ECM) proteins, are key regulators of skin repair and their dysregulation impairs wound healin......

JIF:4.336

Loss-of-function variants within LMOD1 actin-binding site 2 cause pediatric intestinal pseudo-obstruction by impairing protein stability and actin nucleation

期刊: FASEB JOURNAL, 2022; 36 (3)

The leiomodin1 (LMOD1) gene, encoding a potent actin nucleator, was recently reported as a potential pathogenic gene of megacystis-microcolon-intestin......

JIF:4.336

Cardiovascular aspects of the (pro)renin receptor: Function and significance

期刊: FASEB JOURNAL, 2022; 36 (4)

Cardiovascular diseases (CVDs), including all types of disorders related to the heart or blood vessels, are the major public health problems and the l......

JIF:4.336

Ribonucleotide reductase holoenzyme inhibitor COH29 interacts with deubiquitinase ubiquitin-specific protease 2 and downregulates its substrate protein cyclin D1

期刊: FASEB JOURNAL, 2022; 36 (5)

USP2 contributes to the quality control of multiple oncogenic proteins including cyclin D1, Mdm2, Aurora-A, etc., and it is a potential target for ant......

JIF:4.336

Maintenance of glutamine synthetase expression alleviates endotoxin-induced sepsis via alpha-ketoglutarate-mediated demethylation

期刊: FASEB JOURNAL, 2022; 36 (5)

Glutamine synthetase (Glul) is the enzyme that synthesizes endogenous glutamine, which is responsible for critical metabolic pathways and the immune s......

JIF:4.336

HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma

期刊: FASEB JOURNAL, 2022; 36 (6)

Asthma is a disease characterized by airway epithelial barrier destruction, chronic airway inflammation, and airway remodeling. Repeated damage to air......

JIF:4.336

SGLT2 inhibitor dapagliflozin attenuates cardiac fibrosis and inflammation by reverting the HIF-2 alpha signaling pathway in arrhythmogenic cardiomyopathy

期刊: FASEB JOURNAL, 2022; 36 (7)

Excessive cardiac fibrosis and inflammation aberrantly contribute to the progressive pathogenesis of arrhythmogenic cardiomyopathy (ACM). Whether sodi......

JIF:4.336

The autophagy-related degradation of MDA5 by Tembusu virus nonstructural 2B disrupts IFN beta production

期刊: FASEB JOURNAL, 2022; 36 (7)

Duck Tembusu virus (TMUV) is a serious avian pathogen causing a decline in egg production, but the mechanism of the virus that breaks through the inna......

JIF:4.336

CRISPR/Cas9-mediated gene knockout of Sj16 in Schistosoma japonicum eggs upregulates the host-to-egg immune response

期刊: FASEB JOURNAL, 2022; 36 (11)

Schistosomiasis is an important, neglected tropical disease. Schistosoma japonicum can evade host attacks by regulating the host's immunity, causing c......

JIF:4.336

Vitamin D receptor activated by vitamin D administration alleviates Mycobacterium tuberculosis-induced bone destruction by inhibiting NF kappa B-mediated aberrant osteoclastogenesis

期刊: FASEB JOURNAL, 2021; 35 (6)

Clinically, bone destruction caused by Mycobacterium tuberculosis was serious especially in patients with vitamin D (VD) deficiency. However, the role......

Adipose-derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy

期刊: FASEB JOURNAL, 2021; 35 (7)

Tissues undergo a process of degeneration as the body ages. Mesenchymal stem cells (MSCs) have been found to have major potential in delaying the agin......

Downregulation of miR-497-5p prevents liver ischemia-reperfusion injury in association with MED1/TIMP-2 axis and the NF-kappa B pathway

期刊: FASEB JOURNAL, 2021; 35 (4)

Liver ischemia-reperfusion (I/R) injury is a common clinical pathological phenomenon, which is accompanied by the occurrence in liver transplantation.......

Role of epigenetic m(6)A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling

期刊: FASEB JOURNAL, 2021; 35 (5)

N-6-methyladenosine (m6A) methylation is the most prevalent RNA modification, and it emerges as an important regulatory mechanism of gene expression i......

Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to define a pluripotency gene regulatory network

期刊: FASEB JOURNAL, 2021; 35 (6)

The pluripotency gene regulatory network of porcine induced pluripotent stem cells(piPSCs), especially in epigenetics, remains elusive. To determine t......

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