期刊： TRENDS IN CANCER, 2021; 7 (7)
Retrotransposons have been known as major sources of genomic instability that trigger and promote cancer development. In a recent study, Gu et al. rev......
期刊： TRENDS IN CANCER, 2021; 7 (7)
The gastrointestinal tract (GIT) is the largest immune organ and maintains systemic immune homeostasis in the presence of bacterial challenge. Immune ......
期刊： TRENDS IN CANCER, 2021; 7 (6)
Despite the dramatic advances in cancer research over the decades, effective therapeutic strategies are still urgently needed. Increasing evidence ind......
期刊： TRENDS IN CANCER, 2021; 7 (8)
Autophagy is a catabolic intracellular nutrient-scavenging pathway triggered by nutrient deprivation and stress that captures and degrades intracellul......
期刊： TRENDS IN CANCER, 2021; 7 (6)
Nuclear receptors are a family of transcription factors localized in cell nuclei, sensing specific ligands and fine-tuning a variety of cell physiolog......
期刊： TRENDS IN CANCER, 2021; 7 (4)
Most human genes undergo alternative splicing (AS), and dysregulation of alternative splicing contributes to tumor initiation and progression. Computa......
期刊： TRENDS IN CANCER, 2021; 7 (3)
The tumor-suppressor protein p53 is mutated in approximately half of all cancers, whereas the p53 signaling network is perturbed in almost all cancers......
期刊： TRENDS IN CANCER, 2021; 7 (3)
Autologous T cells engineered to express a chimeric antigen receptor (CAR) remain poorly effective against solid tumors, partly because solid neoplasm......
期刊： TRENDS IN CANCER, 2020; 6 (4)
Circular RNA (circRNA) is a class of single-stranded molecules with tissue/development-specific expression patterns. Unlike linear RNA, circRNA forms ......
期刊： TRENDS IN CANCER, 2020; 6 (4)
Patient-derived organoids can recapitulate parental tumor heterogeneity. In a recent study in Cell, Jacob et al. cultivated glioblastoma organoids (GB......
期刊： TRENDS IN CANCER, 2020; 6 (5)
Accelerated tumor repopulation following chemoradiation is often observed in the clinic, but the underlying mechanisms remain unclear. In recent years......
期刊： TRENDS IN CANCER, 2020; 6 (7)
Cancers develop within complex tissue environments consisting of diverse innate and adaptive immune cells, along with stromal cells, vascular networks......
期刊： TRENDS IN CANCER, 2020; 6 (8)
Tumor metastases, that is, the development of secondary tumors in organs distant from the primary tumor, and their treatment remain a serious problem ......
期刊： TRENDS IN CANCER, 2020; 6 (10)
Targeted therapy has become increasingly important in cancer therapy. For example, targeting the promyelocytic leukemia PML protein in leukemia has pr......
期刊： TRENDS IN CANCER, 2020; 6 (6)
Cells can communicate through extracellular vesicle (EV) secretion and uptake. Exosomes are lipid bilayer-enclosed EVs of 30-150 nm in diameter, which......
