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Chinese herbal compound Huangqin Qingrechubi capsule reduces lipid metabolism disorder and inflammatory response in gouty arthritis via the LncRNA H19/APN/PI3K/AKT cascade

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context Gouty arthritis (GA) is a characteristically inflammatory disease often associated with lipid metabolism disorder. Huangqin Qingrechubi capsul......

Protective effect and mechanism of styrax on ischemic stroke rats: metabonomic insights by UPLC-Q/TOF-MS analysis

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context: Styrax is used for prevention and treatment of cerebrovascular diseases. However, the underlying mechanism remains unclear. Objective: To elu......

Lucialdehyde B suppresses proliferation and induces mitochondria-dependent apoptosis in nasopharyngeal carcinoma CNE2 cells

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context Lucialdehyde B (LB), an effective triterpenoid isolated from Ganoderma lucidum (Leyss. ex Fr.) Karst. (Polyproraceae), exerts cytotoxic activi......

The traditional herb Polygonum hydropiper from China: a comprehensive review on phytochemistry, pharmacological activities and applications

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context: Polygonum hydropiper L. (Polygonaceae) (PH) is a traditional Chinese traditional medicine with a pungent flavor and mild drug properties. PH ......

Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still ongoing and currently t......

Danggui Buxue decoction alleviates cyclophosphamide-induced myelosuppression by regulating β-hydroxybutyric acid metabolism and suppressing oxidative stress

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context Danggui Buxue Decoction (DBD) is an effective complementary medicine in alleviating myelosuppression after chemotherapy (MAC). However, its me......

Ligustrazine inhibits inflammatory response of human endometrial stromal cells through the STAT3/IGF2BP1/RELA axis

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context: Endometriosis (EMs) is a gynecological disorder. Ligustrazine has been reported to exert an anti-inflammatory effect on EMs. However, the und......

Repair mechanism of Yishen Tongluo formula on mouse sperm DNA fragmentation caused by polystyrene microplastics

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context Plastics can break down into millions of microplastic (MPs, < 5 mm) particles in the soil and ocean. These MPs can then affect the function......

Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context: Gout is a chronic disease that imposes a huge financial and health burden on patients, which might diminish quality of life. Qin Jiao, a pere......

Sanziguben polysaccharides improve diabetic nephropathy in mice by regulating gut microbiota to inhibit the TLR4/NF-κB/NLRP3 signalling pathway

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context Sanziguben (SZGB) is an empirical prescription used in traditional Chinese medicine to treat diabetic nephropathy (DN). As an abundant and pri......

Evaluation of topical methylene blue nanoemulsion for wound healing in diabetic mice

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context: Diabetic wounds (DW) are a complication of diabetes and slow wound healing is the main manifestation. Methylene blue (MB) has been shown to e......

Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context Guilu-Erxian-Glue (GLEXG) is a traditional Chinese formula used to improve male reproductive dysfunction. Objective To investigate the ferropt......

Mechanism investigation of Duhuo Jisheng pill against rheumatoid arthritis based on a strategy for the integration of network pharmacology, molecular docking and in vivo experimental verification

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context: Duhuo Jisheng pill (DHJS) is a classic traditional Chinese medicine (TCM) formula for rheumatoid arthritis (RA). The effective components and......

Hyperoside ameliorates cerebral ischaemic-reperfusion injury by opening the TRPV4 channel in vivo through the IP3-PKC signalling pathway

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context Hyperoside (Hyp), one of the active flavones from Rhododendron (Ericaceae), has beneficial effects against cerebrovascular disease. However, t......

Isoquinoline alkaloids isolated from Glaucium corniculatum var. corniculatum and Glaucium grandiflorum subsp. refractum var. torquatum with bioactivity studies

期刊: PHARMACEUTICAL BIOLOGY, 2023; 61 (1)

Context: The genus Glaucium Mill., one of the important Papaveraceae family plants, is rich in isoquinoline alkaloids and distributed worldwide. Objec......

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