筛选条件 共查询到500条结果
排序方式
X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation (vol 125, pg 1665, 2015)

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

We determined that this mutation (Y365H) impairs binding of the essential cofactor pyridoxal 5'-phosphate to ALAS2, resulting in destabilization of th......

Quadrivalent VesiculoVax vaccine protects nonhuman primates from viral-induced hemorrhagic fever and death

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

Recent occurrences of filoviruses and the arenavirus Lassa virus (LASV) in overlapping endemic areas of Africa highlight the need for a prophylactic v......

Epitope-specific airway-resident CD4(+) T cell dynamics during experimental human RSV infection

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

BACKGROUND. Respiratory syncytial virus (RSV) is an important cause of acute pulmonary disease and one of the last remaining major infections of child......

Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the magnesium transporter 1 (......

Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of beta-thalassemia

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

beta-Thalassemia is a genetic anemia caused by partial or complete loss of beta-globin synthesis, leading to ineffective erythropoiesis and RBCs with ......

Autoreactive CD8(+) T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

Although most patients with type 1 diabetes (T1D) retain some functional insulin-producing islet beta cells at the time of diagnosis, the rate of furt......

Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

Alterations in gut microbiota impact the pathophysiology of several diseases, including cancer. Radiotherapy (RT), an established curative and palliat......

Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

Pancreatic ductal adenocarcinoma (PDAC) is considered to be a highly immunosuppressive and heterogenous neoplasm. Despite improved knowledge regarding......

A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

An excess of fecal bile acids (BAs) is thought to be one of the mechanisms for diarrhea-predominant irritable bowel syndrome (IBS-D). However, the fac......

Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

Aberrant Tau inclusions in the locus coeruleus (LC) are the earliest detectable Alzheimer's disease-like (AD-like) neuropathology in the human brain. ......

Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have an extremely poor prognosis. VEGF-C has been demonstrated to play vit......

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

Polymorphonuclear neutrophils (PMNs) are increasingly recognized to influence solid tumor development, but why their effects are so context dependent ......

U3-1402 sensitizes HER3-expressing tumors to PD-1 blockade by immune activation

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

Immunotherapy targeting programmed cell death-1 (PD-1) induces durable antitumor efficacy in many types of cancer. However, such clinical benefit is l......

GPR101 mediates the pro-resolving actions of RvD5(n-3 DPA)in arthritis and infections

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1)

N-3 docosapentaenoic acid-derived resolvin D5 (RvD5(n-3 DPA)) is diurnally regulated in peripheral blood and exerts tissueprotective actions during in......

共500条页码: 1/34页15条/页
打开APP