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Recruitment of RBM6 to DNA Double-Strand Breaks Fosters Homologous Recombination Repair

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (3)

DNA double-strand breaks (DSBs) are highly toxic lesions that threaten genome integrity and cell survival. To avoid harmful repercussions of DSBs, a w......

Degradation of CDK9 by Ubiquitin E3 Ligase STUB1 Regulates P-TEFb Level and Its Functions for Global Target Gene Expression within Mammalian Cells

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (9)

Positive transcription elongation factor b (P-TEFb) regulates expression of diverse sets of genes within mammalian cells that have implications in sev......

Receptor Recycling by Retromer

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (7)

The highly conserved retromer complex controls the fate of hundreds of receptors that pass through the endolysosomal system and is a central regulator......

A CDK-Dependent Phosphorylation of a Novel Domain of Rif1 Regulates its Function during Telomere Damage and Other Types of Stress

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (5)

Rif1 mediates telomere length, DNA replication, and DNA damage responses in budding yeast. Previous work identified several posttranslational modifica......

Incomplete Elongation of Ultra-long-chain Polyunsaturated Acyl-CoAs by the Fatty Acid Elongase ELOVL4 in Spinocerebellar Ataxia Type 34

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (2)

Spinocerebellar ataxias (SCAs) are autosomal dominant diseases characterized by cerebellar atrophy and ataxia. The SCA subtype SCA34 is caused by spec......

Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (4)

The ability of cells to communicate with their surrounding is a prerequisite for essential processes such as proliferation, apoptosis, migration, and ......

EPRS1 Controls the TGF-β Signaling Pathway via Interaction with TβRI in Hepatic Stellate Cell

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (5)

Glutamyl-prolyl-tRNA synthetase 1 (EPRS1) is known to associated with fibrosis through its catalytic activity to produce prolyl-tRNA. Although its cat......

Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; ()

During the inflammatory response, macrophage phenotypes can be broadly classified as pro-inflammatory/classically activated M1, or pro-resolving/alter......

Claspin is Required for Growth Recovery from Serum Starvation through Regulating the PI3K-PDK1-mTOR Pathway in Mammalian Cells

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (1)

Claspin plays multiple important roles in regulation of DNA replication as a mediator for the cellular response to replication stress, an integral rep......

Functional Consequences of Shifting Transcript Boundaries in Glucose Starvation

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (11)

Glucose is a major source of carbon and essential for the survival of many organisms, ranging from yeast to human. A sudden 60-fold reduction of gluco......

The LINC between Δ40p53-miRNA Axis in the Regulation of Cellular Homeostasis

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (7)

Previous research has shown that Delta 40p53, the translational isoform of p53, can inhibit cell growth independently of p53 by regulating microRNAs. ......

The Sequential Recruitments of Rab-GTPase Ypt1p and the NNS Complex onto pre-HAC1 mRNA Promote Its Nuclear Degradation in Baker's Yeast

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; ()

Induction of unfolded protein response involves activation of transcription factor Hac1p that is encoded by HAC1 pre-mRNA harboring an intron and a bi......

RNA Polymerase II Dependent Crosstalk between H4K16 Deacetylation and H3K56 Acetylation Promotes Transcription of Constitutively Expressed Genes

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2023; 43 (11)

Nucleosome dynamics in the coding region of a transcriptionally active locus is critical for understanding how RNA polymerase II progresses through th......

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