期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (5)
Nanomedicine has attracted increasing attention and emerged as a safer and more effective modality in cancer treatment than conventional chemotherapy.......
期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (6)
Stroke is a common cause of death and disability. Allisartan isoproxil (ALL) is a new angiotensin II receptor blocker and a new antihypertensive drug ......
期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (8)
FOXO3a (forkhead box transcription factor 3a) is involved in regulating multiple biological processes in cancer cells. BNIP3 (Bcl-2/adenovirus E1B 19-......
期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (8)
Voltage-gated sodium channel Nav1.7 robustly expressed in peripheral nociceptive neurons has been considered as a therapeutic target for chronic pain,......
期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (8)
Hemorrhagic transformation (HT) is a common serious complication of stroke after thrombolysis treatment, which limits the clinical use of tissue plasm......
期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (8)
Brexpiprazole (Bre) is a new multi-target antipsychotic drug (APD) approved by the US FDA in 2015, and shows good therapeutic potential. But it lacks ......
期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (9)
Non-small cell lung cancer (NSCLC) is characterized by a high incidence of metastasis and poor survival. As epithelial-mesenchymal transition (EMT) is......
期刊: ACTA PHARMACOLOGICA SINICA, ; ()
Incomplete recovery from episodes of acute kidney injury (AKI) can predispose patients to develop chronic kidney disease (CKD). Although hypoxia-induc......
期刊: ACTA PHARMACOLOGICA SINICA, ; ()
RAS-driven colorectal cancer relies on glucose metabolism to support uncontrolled growth. However, monotherapy with glycolysis inhibitors like 2-deoxy......
期刊: ACTA PHARMACOLOGICA SINICA, ; ()
NOD-like receptor (NLR) family pyrin domain-containing-3 (NLRP3) inflammasome is implicated in inflammation-associated diseases such as multiple scler......
期刊: ACTA PHARMACOLOGICA SINICA, ; ()
Immune checkpoint inhibition is an important strategy in cancer therapy. Blockade of CTLA-4 and PD-1/PD-L1 is well developed in clinical practice. In ......
期刊: ACTA PHARMACOLOGICA SINICA, ; ()
Ionizing radiation-induced intestinal injury is a catastrophic complication in patients receiving radiotherapy. Circulating exosomes from patients und......
期刊: ACTA PHARMACOLOGICA SINICA, ; ()
Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease with a poor prognosis. Emerging evidence has revealed that targeting senescent cell......
期刊: ACTA PHARMACOLOGICA SINICA, ; ()
Sulfur mustard (SM) is a highly toxic chemical warfare agent that causes acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). Th......