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Lipid/PAA-coated mesoporous silica nanoparticles for dual-pH-responsive codelivery of arsenic trioxide/paclitaxel against breast cancer cells

期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (5)

Nanomedicine has attracted increasing attention and emerged as a safer and more effective modality in cancer treatment than conventional chemotherapy.......

Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage

期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (6)

Stroke is a common cause of death and disability. Allisartan isoproxil (ALL) is a new angiotensin II receptor blocker and a new antihypertensive drug ......

FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy

期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (8)

FOXO3a (forkhead box transcription factor 3a) is involved in regulating multiple biological processes in cancer cells. BNIP3 (Bcl-2/adenovirus E1B 19-......

Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain

期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (8)

Voltage-gated sodium channel Nav1.7 robustly expressed in peripheral nociceptive neurons has been considered as a therapeutic target for chronic pain,......

Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites

期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (8)

Hemorrhagic transformation (HT) is a common serious complication of stroke after thrombolysis treatment, which limits the clinical use of tissue plasm......

Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats

期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (8)

Brexpiprazole (Bre) is a new multi-target antipsychotic drug (APD) approved by the US FDA in 2015, and shows good therapeutic potential. But it lacks ......

Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting beta-catenin-mediated epithelial-mesenchymal transition

期刊: ACTA PHARMACOLOGICA SINICA, 2021; 42 (9)

Non-small cell lung cancer (NSCLC) is characterized by a high incidence of metastasis and poor survival. As epithelial-mesenchymal transition (EMT) is......

FIH-1-modulated HIF-1 alpha C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling

期刊: ACTA PHARMACOLOGICA SINICA, ; ()

Incomplete recovery from episodes of acute kidney injury (AKI) can predispose patients to develop chronic kidney disease (CKD). Although hypoxia-induc......

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin

期刊: ACTA PHARMACOLOGICA SINICA, ; ()

RAS-driven colorectal cancer relies on glucose metabolism to support uncontrolled growth. However, monotherapy with glycolysis inhibitors like 2-deoxy......

1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis

期刊: ACTA PHARMACOLOGICA SINICA, ; ()

NOD-like receptor (NLR) family pyrin domain-containing-3 (NLRP3) inflammasome is implicated in inflammation-associated diseases such as multiple scler......

Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1

期刊: ACTA PHARMACOLOGICA SINICA, ; ()

Immune checkpoint inhibition is an important strategy in cancer therapy. Blockade of CTLA-4 and PD-1/PD-L1 is well developed in clinical practice. In ......

Exosomes are involved in total body irradiation-induced intestinal injury in mice

期刊: ACTA PHARMACOLOGICA SINICA, ; ()

Ionizing radiation-induced intestinal injury is a catastrophic complication in patients receiving radiotherapy. Circulating exosomes from patients und......

Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells

期刊: ACTA PHARMACOLOGICA SINICA, ; ()

Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease with a poor prognosis. Emerging evidence has revealed that targeting senescent cell......

BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A-YAP axis

期刊: ACTA PHARMACOLOGICA SINICA, ; ()

Sulfur mustard (SM) is a highly toxic chemical warfare agent that causes acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). Th......

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