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LRRC3B Polymorphisms Contributed to Breast Cancer Susceptibility in Chinese Han Population

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Purpose LRRC3B gene, as a tumor suppressor gene was involved in the development and progress of breast cancer (BC). However, the effect of LRRC3B poly......

Prognostic Biomarkers on a Competitive Endogenous RNA Network Reveals Overall Survival in Triple-Negative Breast Cancer

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

The objective of this study was to construct a competitive endogenous RNA (ceRNA) regulatory network using differentially expressed long noncoding RNA......

Identification of Somatic Genetic Alterations Using Whole-Exome Sequencing of Uterine Leiomyosarcoma Tumors

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Background The genomic abnormalities associated with uterine leiomyosarcoma (uLMS) have not been fully elucidated to date. Objective To understand the......

Diagnostic Accuracy of the ADNEX Model for Ovarian Cancer at the 15% Cut-Off Value: A Systematic Review and Meta-Analysis

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Objectives To evaluate the diagnostic accuracy of the ADNEX model for ovarian cancer at the 15% cut-off value. Methods Studies on the identified diagn......

Application of Diffusion Weighted Imaging Techniques for Differentiating Benign and Malignant Breast Lesions

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

To explore the value of apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM), and diffusional kurtosis imaging (DKI) based on dif......

Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Non-small cell lung cancer (NSCLC) has the highest morbidity and mortality among all carcinomas. However, it is difficult to diagnose in the early sta......

PGK1 Is a Key Target for Anti-Glycolytic Therapy of Ovarian Cancer: Based on the Comprehensive Analysis of Glycolysis-Related Genes

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Reprogramming of energy metabolism is a key hallmark of cancer, which provides a new research perspective for exploring the development of cancer. How......

The Prognosis and Feasibility of Extensive Clinical Target Volume in Postoperative Radiotherapy for Esophageal Squamous Cell Carcinoma: A Phase II Clinical Trial

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Background This trial aims to explore the feasibility and safety of postoperative radiotherapy covering all regional lymph node areas for locally adva......

Suppressing ERK Pathway Impairs Glycochenodeoxycholate-Mediated Survival and Drug-Resistance in Hepatocellular Carcinoma Cells

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Glycochenodeoxycholate (GCDA), a toxic component in bile salts, is involved in carcinogenesis of gastrointestinal tumors. The objective of this resear......

Postoperative Radiotherapy for Patients With Resectable Stage III-N2 Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Purpose: For resectable cases of stage III-N2 non-small cell lung cancer (NSCLC), the best treatment after surgery is still uncertain. The effect of p......

Loss of IL-34 Expression Indicates Poor Prognosis in Patients With Lung Adenocarcinoma

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Interleukin 34 (IL-34), an additional ligand of the colony-stimulating factor-1 receptor (CSF-1R), promotes the secretion of pro-inflammatory cytokine......

Management of Clinically Involved Lateral Lymph Node Metastasis in Locally Advanced Rectal Cancer: A Radiation Dose Escalation Study

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Background Patients with lateral lymph nodes (LLNs) metastasis are not effectively treated with neoadjuvant chemoradiotherapy. This study aimed to com......

Pyroptosis, a New Breakthrough in Cancer Treatment

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

The way of cell death can be roughly divided into two categories: cell necrosis and PCD(programmed cell death). Pyroptosis is a kind of PCD, its occur......

The COX10-AS1/miR-641/E2F6 Feedback Loop Is Involved in the Progression of Glioma

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Glioma is the most common primary tumour of the central nervous system and is considered one of the greatest challenges for neurosurgery. Mounting evi......

Radiomic Feature-Based Nomogram: A Novel Technique to Predict EGFR-Activating Mutations for EGFR Tyrosin Kinase Inhibitor Therapy

期刊: FRONTIERS IN ONCOLOGY, 2021; 11 ()

Objectives: To develop and validate a radiomic feature-based nomogram for preoperative discriminating the epidermal growth factor receptor (EGFR) acti......

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