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Clinicopathological Features and Outcomes of Acute Kidney Injury in Critically Ill COVID-19 with Prolonged Disease Course: A Retrospective Cohort

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (9)

Background The incidence, severity, and outcomes of AKI in COVID-19 varied in different reports. In patients critically ill with COVID-19, the clinico......

Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (9)

Background Gentamicin is a potent aminoglycoside antibiotic that targets gram-negative bacteria, but nephrotoxicity limits its clinical application. T......

LIM-Nebulette Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin Filaments

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (10)

Background Maintenance of the intricate interdigitating morphology of podocytes is crucial for glomerular filtration. One of the key aspects of specia......

Sympathetic Overactivity in CKD Disrupts Buffering of Neurotransmission by Endothelium-Derived Hyperpolarizing Factor and Enhances Vasoconstriction

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (10)

Background Hypertension commonly complicates CKD. Vascular smooth muscle cells (VSMCs) of resistance arteries receive signals from the sympathetic ner......

Multifunctional Natural Polymer Nanoparticles as Antifibrotic Gene Carriers for CKD Therapy

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (10)

Background Progressive fibrosis is the underlying pathophysiological process of CKD, and targeted prevention or reversal of the profibrotic cell pheno......

A Randomized Trial on the Effect of Phosphate Reduction on Vascular End Points in CKD (IMPROVE-CKD)

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (11)

Background Hyperphosphatemia is associated with increased fibroblast growth factor 23 (FGF23), arterial calcification, and cardiovascular mortality. E......

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (1)

Background Renal endothelial cells from glomerular, cortical, and medullary kidney compartments are exposed to different microenvironmental conditions......

Additive Therapeutic Effects of Mesenchymal Stem Cells and IL-37 for Systemic Lupus Erythematosus

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (1)

Background Although mesenchymal stem cells (MSCs) might offer a promising strategy for treating SLE, their immunoregulatory plasticity makes their the......

A Modified Peptide Derived from Goodpasture Autoantigen Arrested and Attenuated Kidney Injuries in a Rat Model of Anti-GBM Glomerulonephritis

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (1)

Background In Goodpasture disease, the noncollagenous domain 1 of the alpha 3 chain (alpha 3NC1) of type IV collagen is the main target antigen of ant......

Whole-Genome Sequencing of Finnish Type 1 Diabetic Siblings Discordant for Kidney Disease Reveals DNA Variants associated with Diabetic Nephropathy

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (2)

Background Several genetic susceptibility loci associated with diabetic nephropathy have been documented, but no causative variants implying novel pat......

Kinin B1 Receptor Is Important in the Pathogenesis of Myeloperoxidase-Specific ANCA GN

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (2)

Background Myeloperoxidase-specific ANCA (MPO-ANCA) are implicated in the pathogenesis of vasculitis and GN. Kinins play a major role during acute inf......

The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (2)

Background Mononuclear phagocytes (MPs), including macrophages, monocytes, and dendritic cells (DCs), are phagocytic cells with important roles in imm......

alpha 2A-Adrenoceptors Modulate Renal Sympathetic Neurotransmission and Protect against Hypertensive Kidney Disease

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (4)

Background Increased nerve activity causes hypertension and kidney disease. Recent studies suggest that renal denervation reduces BP in patients with ......

Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (12)

Background Eighteen known susceptibility loci for IgAN account for only a small proportion of IgAN risk. Methods Genome-wide meta-analysis was perform......

Murine Epsins Play an Integral Role in Podocyte Function

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020; 31 (12)

Background Epsins, a family of evolutionarily conserved membrane proteins, play an essential role in endocytosis and signaling in podocytes. Methods P......

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