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No evidence for brain renin-angiotensin system activation during DOCA-salt hypertension

期刊: CLINICAL SCIENCE, 2021; 135 (2)

Brain renin-angiotensin system (RAS) activation is thought to mediate deoxycorticosterone acetate (DOCA)-salt hypertension, an animal model for human ......

SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome

期刊: CLINICAL SCIENCE, 2021; 135 (12)

Chronic hepatitis B virus (HBV) infection is a significant public health burden worldwide. HBV covalently closed circular DNA (cccDNA) organized as a ......

Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor

期刊: CLINICAL SCIENCE, 2021; 135 (6)

Until now, renin-angiotensin system (RAS) hyperactivity was largely thought to result from angiotensin II (Ang II)-dependent stimulation of the Ang II......

Gastrin, via activation of PPAR alpha, protects the kidney against hypertensive injury

期刊: CLINICAL SCIENCE, 2021; 135 (2)

Hypertensive nephropathy (HN) is a common cause of end-stage renal disease with renal fibrosis; chronic kidney disease is associated with elevated ser......

Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/beta-catenin/autophagy axis

期刊: CLINICAL SCIENCE, 2021; 135 (15)

Although accelerated cellular senescence is closely related to the progression of chronic kidney disease (CKD) and renal fibrosis, the underlying mech......

KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages

期刊: CLINICAL SCIENCE, 2021; 135 (4)

Tumor microenvironment (TME) exerts key roles in pancreatic ductal adenocarcinoma (PDAC) development. However, the factors regulating the cross-talk b......

IGF2 deficiency causes mitochondrial defects in skeletal muscle

期刊: CLINICAL SCIENCE, 2021; 135 (7)

Exercise training improves muscle fitness in many aspects, including induction of mitochondrial biogenesis and maintenance of mitochondrial dynamics. ......

A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis

期刊: CLINICAL SCIENCE, 2021; 135 (14)

Epigenetic dysregulation has long been identified as a key driver of leukemogenesis in acute myeloid leukemia (AML). However, epigenetic drugs such as......

Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress

期刊: CLINICAL SCIENCE, 2021; 135 (14)

Recent studies reveal that bile acid metabolite composition and its metabolism are changed in metabolic disorders, such as obesity, type 2 diabetes an......

Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes

期刊: CLINICAL SCIENCE, 2021; 135 (4)

The high disability, mortality and morbidity of diabetic ulcers make it urgent to explore effective strategies for diabetic wound repair. TrxR1 plays ......

Protective role of kallistatin in renal fibrosis via modulation of Wnt/beta-catenin signaling

期刊: CLINICAL SCIENCE, 2021; 135 (3)

Kallistatin is a multiple functional serine protease inhibitor that protects against vascular injury, organ damage and tumor progression. Kallistatin ......

Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury

期刊: CLINICAL SCIENCE, 2021; 135 (7)

Liver diseases present a significant public health burden worldwide. Although the mechanisms of liver diseases are complex, it is generally accepted t......

Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney

期刊: CLINICAL SCIENCE, 2021; 135 (15)

In the present study, we tested the hypothesis that there are significant sex differences in angiotensin II (Ang II)-induced hypertension and kidney i......

SOX7 suppresses endothelial-to-mesenchymal transitions by enhancing VE-cadherin expression during outflow tract development

期刊: CLINICAL SCIENCE, 2021; 135 (6)

The endothelial-to-mesenchymal transition (EndMT) is a critical process that occurs during the development of the outflow tract (OFT). Malformations o......

cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7

期刊: CLINICAL SCIENCE, 2021; 135 (11)

We aimed to investigate the role of cMet agonistic antibody (cMet Ab) in preventing kidney fibrosis during acute kidney injury (AKI) to chronic kidney......

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