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Pediatric reference interval verification for 17 specialized immunoassays and cancer markers on the Abbott Alinity i system in the CALIPER cohort of healthy children and adolescents

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2023; 61 (1)

Objectives Clinical laboratory investigation of autoimmune, metabolic, and oncologic disorders in children and adolescents relies on appropriateness o......

Mucin 13 (MUC13) as a candidate biomarker for ovarian cancer detection: potential to complement CA125 in detecting non-serous subtypes

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2023; 61 (3)

Objectives Ovarian cancer is the most lethal gynecological malignancy in developed countries. One of the key associations with the high mortality rate......

Harmonization of indirect reference intervals calculation by the Bhattacharya method

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2023; 61 (2)

Objectives: The aim of this study was to harmonize the criteria for the Bhattacharya indirect method Microsoft Excel Spreadsheet for reference interva......

Reference intervals for thyroid biomarkers to enhance the assessment of thyroid status in childhood and adolescence

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2023; 61 (7)

Objectives: The determination of assay-dependent upper and lower reference limits (URL, LRL) of free triiodothyronine (FT3), free thyroxine (FT4), and......

The European Register of Specialists in Clinical Chemistry and Laboratory Medicine: code of conduct, version 3-2023

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2023; 61 (6)

Whilst version 2 focussed on the professional conduct expected of a Specialist in Laboratory Medicine, version 3 builds on the responsibilities for et......

The laboratory journey to become a decision engine: a roadmap for diagnostic transformation

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2023; 61 (4)

Laboratories and diagnostic departments are presiding over a massive amount of data they are failing to fully leverage it. Data is the new black gold ......

Clinical evidence requirements according to the IVDR 2017/746: practical tools and references for underpinning clinical evidence of IVD-MDs

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2023; 61 (7)

In May 2022, the European Regulation 2017/746 (IVDR) came into force. It changes the approach of in vitro medical devices (IVD-MDs) for industry and i......

D-dimer: old dogmas, new (COVID-19) tricks

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2023; 61 (5)

D-dimer is a fibrin degradation product encompassing multiple cross-linked D domains and/or E domains present in the original fibrinogen molecule, who......

Where is laboratory medicine headed in the next decade? Partnership model for efficient integration and adoption of artificial intelligence into medical laboratories

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2023; 61 (4)

Objectives The field of artificial intelligence (AI) has grown in the past 10 years. Despite the crucial role of laboratory diagnostics in clinical de......

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