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Combined scaffold hopping, molecular screening with dynamic simulation to screen potent CRBN ligands

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2021; 122 (9)

Thalidomide and its derivatives lenalidomide and pomalidomide, known as immunomodulatory drugs, (IMiDs) bind directly to cereblon (CRBN), a substrate ......

Herkinorin negatively regulates NLRP3 inflammasome to alleviate neuronal ischemic injury through activating Mu opioid receptor and inhibiting the NF-kappa B pathway

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2021; 122 (9)

Herkinorin is a novel opioid receptor agonist. Activation of opioid receptors, a member of G protein coupled receptors (GPCRs), may play an important ......

Comprehensive bioinformatics analysis reveals kinase activity profiling associated with heart failure

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2021; 122 (9)

Heart failure is a complex clinical syndrome originating from cardiac injury, which leads to considerable morbidity and mortality. Among the dynamic m......

Phosphorylated LASS2 inhibits prostate carcinogenesis via negative regulation of Wnt/beta-catenin signaling

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2021; 122 (9)

LASS2 is a novel tumor-suppressor gene and has been characterized as a ceramide synthase, which synthesizes very-long acyl chain ceramides. However, L......

Diagnostic and therapeutic potencies of miR-18a-5p in mixed-type gastric adenocarcinoma

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2021; 122 (9)

Mixed-type gastric adenocarcinoma (by Lauren Classification) has poor clinical outcomes with few targeted treatment options. The primary objective of ......

GPR30 knockdown weakens the capacity of CAF in promoting prostate cancer cell invasion via reducing macrophage infiltration and M2 polarization

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2021; 122 (9)

Cancer-associated fibroblasts (CAFs) can promote the development and metastasis of prostate cancer partly by mediating tumor-associated inflammation. ......

Calmodulin/CaMKII-gamma mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, ; ()

Calmodulin (CaM), a Ca2+ binding protein, plays a critical role in cancer initiation and progression through binding and activating numerous target pr......

TBX2/3 is required for regeneration of dorsal-ventral and medial-lateral polarity in planarians

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, ; ()

The molecular mechanisms responsible for axis establishment during non-embryonic processes remain elusive. The planarian flatworm is an ideal model or......

Extracellular vesicles and the regulation of tumor immunity: Current progress and future directions

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, ; ()

As nano-level information carriers, extracellular vesicles (EVs) contain proteins, DNA or RNA, which maintain the transmembrane transport of biomolecu......

SLC6A15 acts as a tumor suppressor to inhibit migration and invasion in human papillary thyroid cancer

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, ; ()

Solute Carrier Family 6 Member 15 (SLC6A15), a sodium-dependent neutral amino acid transporter, has been found with dysregulated expression in several......

HnRNPA2B1 promotes the proliferation of breast cancer MCF-7 cells via the STAT3 pathway

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2021; 122 (3-4)

HnRNPA2/B1 is highly expressed in many tumors. However, the role of hnRNPA2/B1 in breast cancer is not clear. In this study, we found the proliferatio......

MiR-455-5p monitors myotube morphogenesis by targeting mylip

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2021; 122 (3-4)

As a posttranscriptional regulatory factor, microRNA (miRNA) plays an important role in the formation of myotubes. However, little is known about the ......

Activation of Bombyx mori neuropeptide G protein-coupled receptor A19 by neuropeptide RYamides couples to G(q) protein-dependent signaling pathways

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2021; 122 (3-4)

RYamides constitute a novel family of neuropeptides newly identified in insects, and play important roles in regulating a variety of physiological pro......

miR-218 contributes to drug resistance in multiple myeloma via targeting LRRC28

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2021; 122 (3-4)

Multiple myeloma (MM) is a malignant neoplasm featured by obvious drug resistance and poor prognosis. MicroRNAs (miRNAs) are a class of small noncodin......

Hsa_circ_0031288/hsa-miR-139-3p/Bcl-6 regulatory feedback circuit influences the invasion and migration of cervical cancer HeLa cells

期刊: JOURNAL OF CELLULAR BIOCHEMISTRY, 2020; 121 (10)

Circular RNA (circRNA) molecules contain microRNA (miRNA) response elements that are able to competitively bind miRNAs as well as function as miRNA sp......

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