期刊： CANCER CELL, 2022; 40 (10)
We present the largest whole-genome sequencing (WGS) study of non-small cell lung cancer (NSCLC) to date among 6,004 individuals of Chinese ancestry, ......
Despite the unprecedented success of immune checkpoint inhibitors (ICIs) as anti-cancer therapy, it remains a prevailing clinical need to identify add......
In a recent Science study, an advanced mutational signature analysis was performed on an unprecedentedly large set of cancer whole-genome sequences ac......
期刊： CANCER CELL, 2022; 40 (12)
Cancer-associated fibroblasts (CAFs) play a role in response to cancer treatment and patient prognosis. CAFs show phenotypic and functional heterogene......
期刊： CANCER CELL, 2022; 40 (11)
The leukocyte Fcy receptor (FcyR)-mediated response is important for the efficacy of therapeutic antibodies; however, little is known about the role o......
Cisplatin-based chemotherapy remains the primary treatment for unresectable and metastatic muscle -inva-sive bladder cancers (MIBCs). However, tumors ......
We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA) using paired tumor and adjacent liver tissues from 262 patients.......
The tumor microenvironment (TME) is connected to immunotherapy responses, but it remains unclear how cancer cells and host tissues differentially infl......
Two recent reports in the New England Journal of Medicine highlight the successful application of novel tar-geted therapies to improve the clinical ou......
期刊： CANCER CELL, 2022; 40 (11)
Prostate cancer adeno-to-neuroendocrine lineage transition has emerged as a mechanism of targeted ther-apeutic resistance. Identifying the direct mole......
Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (Clinic......
期刊： CANCER CELL, 2022; 40 (12)
N6-Methyladenosine (m(6)A) modification and its modulators play critical roles and show promise as therapeutic targets in human cancers, including acu......
期刊： CANCER CELL, 2022; 40 (10)
How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages (TAMs) needs further investigation. Here we show that M2-like TAMs......
