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LncRNA SOX21-AS1 Promotes the Growth and Invasiveness of Osteosarcoma Cells Through miR-7-5p/IRS2 Regulatory Network

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (3)

Background. Osteosarcoma (OS) is commonly known as a bone malignancy, causing a mass of lethality worldwide. Long coding RNAs (lncRNAs) have been wide......

LncRNA PRNCR1 Promotes Breast Cancer Proliferation and Inhibits Apoptosis by Modulating microRNA-377/CCND2/MEK/MAPK Axis

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (5)

Background. Long non-coding RNAs (lncRNAs) have recently become the vital gene regulators in diverse cancers. In our study, we purposed to inquiry int......

Inhibition of Androgen Receptor Signaling Promotes Prostate Cancer Cell Migration via Upregulation of Annexin A1 Expression

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (2)

Background. Recent studies indicate that androgen deprivation therapy (ADT), the main therapeutic approach for metastatic prostate cancer (PCa), accel......

Dysregulation of the miR-1275/HK2 Axis Contributes to the Progression of Hypoxia/Reoxygenation-Induced Myocardial Injury

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (5)

Objective. This research was designed to investigate the function of miR-1275 in hypoxia/reoxygenation (H/R)-induced myocardial injury and its in-dept......

Papaverine Perfusion via the Aortic Root before Heart Re-beating Alleviates Myocardial Injury after Heart Valve Replacement

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (4)

Aim. Myocardial injury is inevitable during cardiac surgical procedures and reducing myocardial injury in patients with CPB surgery is the focus of cu......

Dexmedetomidine Attenuates Lung Injury in Toxic Shock Rats by Inhibiting Inflammation and Autophagy

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (3)

Objective. To explore the mechanisms whereby dexmedetomidine reversed lung injury in rats with toxic shock via inhibiting inflammation and autophagy. ......

Long Noncoding RNA MIAT Regulates the Process of Laryngeal Squamous Cell Carcinoma Through Regulation of miR-147a/BCOR

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (4)

Background. Myocardial infarction associated transcript (MIAT) is a long non-coding RNA (lncRNA) that can play oncogenic role in different kinds of ca......

microRNA-103 Contributes to Progression of Polycystic Ovary Syndrome Through Modulating the IRS1/PI3K/AKT Signal Axis

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (5)

Background. Polycystic ovary syndrome (PCOS) is a frequent gynecological endocrine disorder, and the majority of PCOS patients experience different de......

Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting C-X-C Motif Chemokine Ligand 6

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (1)

Background and aims. C-X-C Motif Chemokine Ligand 6 (CXCL6) is an important chemokine. We attempt in this investigation to explore its role and possib......

MicroRNA-221 Promotes Cell Proliferation and Inhibits Apoptosis in Osteosarcoma Cells by Directly Targeting FBXW11 and Regulating Wnt Signaling

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (2)

Background and objectives. MicroRNAs play a crucial role in the progression of various cancers, and microRNA-221 (miR-221) has been observed to be sig......

Effect of Irisin on Pressure Overload-Induced Cardiac Remodeling

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (2)

Background. Irisin has been considered a prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of iris......

Tumor-derived Exosomes Induced M2 Macrophage Polarization and Promoted the Metastasis of Osteosarcoma Cells Through Tim-3

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (2)

Introduction. Osteosarcoma, the most prevalent primary malignancy of the bone, is often presented with high-grade subclinical metastatic disease that ......

Genetic Variation in VKORC1 and Risk for Osteoporosis

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (2)

Background and Aims. The vitamin K epoxide reductase complex subunit 1 (VKORC1) plays an important role in bone development and bone metabolism by inf......

Increasing Imbalance of Treg/Th17 Indicates More Severe Glucose Metabolism Dysfunction in Overweight/obese Patients

期刊: ARCHIVES OF MEDICAL RESEARCH, 2021; 52 (3)

Background. Chronic low-grade inflammation and dysfunction of metabolism has been reported to be involved in obesity. Regulatory T cell (Treg) and hel......

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