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Camptothecin effectively treats obesity in mice through GDF15 induction

期刊: PLOS BIOLOGY, 2022; 20 (2)

Elevated circulating levels of growth differentiation factor 15 (GDF15) have been shown to reduce food intake and lower body weight through activation......

JIF:7.279

Dynamic changes in brain lateralization correlate with human cognitive performance

期刊: PLOS BIOLOGY, 2022; 20 (3)

Hemispheric lateralization constitutes a core architectural principle of human brain organization underlying cognition, often argued to represent a st......

JIF:7.279

RSK1 promotes mammalian axon regeneration by inducing the synthesis of regeneration-related proteins

期刊: PLOS BIOLOGY, 2022; 20 (6)

In contrast to the adult mammalian central nervous system (CNS), the neurons in the peripheral nervous system (PNS) can regenerate their axons. Howeve......

JIF:7.279

Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3 beta

期刊: PLOS BIOLOGY, 2022; 20 (4)

Skeletal muscle regeneration is essential for maintaining muscle function in injury and muscular disease. Myogenesis plays key roles in forming new my......

JIF:7.279

Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR

期刊: PLOS BIOLOGY, 2022; 20 (1)

Lipid droplets (LDs) have increasingly been recognized as an essential organelle for eukaryotes. Although the biochemistry of lipid synthesis and degr......

JIF:7.279

Metacognition and mentalizing are associated with distinct neural representations of decision uncertainty

期刊: PLOS BIOLOGY, 2022; 20 (5)

Metacognition and mentalizing are both associated with meta-level mental state representations. Conventionally, metacognition refers to monitoring one......

JIF:7.279

Single-cell multiomics analyses of spindle-transferred human embryos suggest a mostly normal embryonic development

期刊: PLOS BIOLOGY, 2022; 20 (8)

Mitochondrial DNA (mtDNA) mutations are often associated with incurable diseases and lead to detectable pathogenic variants in 1 out of 200 babies. Un......

JIF:7.279

HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma

期刊: PLOS BIOLOGY, 2021; 19 (4)

Renal cell carcinoma (RCC) is responsible for most cases of the kidney cancer. Previous research showed that low serum levels of cholesterol level pos......

A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects

期刊: PLOS BIOLOGY, 2021; 19 (8)

Pathogenic fungi precisely respond to dynamic microenvironments during infection, but the underlying mechanisms are not well understood. The insect pa......

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5

期刊: PLOS BIOLOGY, 2021; 19 (8)

Tumor necrosis factor receptor-1 (TNFR1) signaling, apart from its pleiotropic functions in inflammation, plays a role in embryogenesis as deficiency ......

IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice

期刊: PLOS BIOLOGY, 2021; 19 (8)

Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that inter......

BDNF produced by cerebral microglia promotes cortical plasticity and pain hypersensitivity after peripheral nerve injury

期刊: PLOS BIOLOGY, 2021; 19 (7)

Peripheral nerve injury-induced mechanical allodynia is often accompanied by abnormalities in the higher cortical regions, yet the mechanisms underlyi......

The structure of MgtE in the absence of magnesium provides new insights into channel gating

期刊: PLOS BIOLOGY, 2021; 19 (4)

MgtE is a Mg2+ channel conserved in organisms ranging from prokaryotes to eukaryotes, including humans, and plays an important role in Mg2+ homeostasi......

FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria

期刊: PLOS BIOLOGY, 2021; 19 (6)

Little is known about mechanisms of membrane fission in bacteria despite their requirement for cytokinesis. The only known dedicated membrane fission ......

Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants

期刊: PLOS BIOLOGY, 2021; 19 (7)

Synaptotagmin-7 (Syt7) plays direct or redundant Ca2+ sensor roles in multiple forms of vesicle exocytosis in synapses. Here, we show that Syt7 is a r......

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