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Large-scale survey of parental antibiotic use for paediatric upper respiratory tract infections in China: implications for stewardship programmes and national policy

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 57 (4)

BACKGROUND: Inappropriate use of antibiotics for upper respiratory tract infections (URTIs) in Chinese children is rampant. Parents' decision-making p......

Molecular genetic characteristics of mcr-9-harbouring Salmonella enterica serotype Typhimurium isolated from raw milk *

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 57 (5)

Among the 10 reported mcr genes, mcr 9 was first identified in Salmonella enterica serotype Typhimurium, which is a leading cause of foodborne illness......

Dual therapy with dolutegravir plus boosted protease inhibitor as maintenance or salvage therapy in highly experienced people living with HIV

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 58 (3)

Real-world experience with dolutegravir (DTG) plus boosted protease inhibitor (bPI) as a two-drug regimen is limited for highly experienced HIV-positi......

Dysbiosis of the rat vagina is efficiently rescued by vaginal microbiota transplantation or probiotic combination

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 57 (3)

Vaginal dysbiosis is characterised by a disturbed vaginal microbiota and is associated with various gynaecological diseases. Owing to its high recurre......

Species distribution and antifungal susceptibilities of clinical isolates of Penicillium and Talaromyces species in China

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 58 (1)

Morphologically identified Penicillium (n = 103) and Talaromyces marneffei (n = 8) isolates were collected from various clinical sources between 2016 ......

Antibiotic strategies and clinical outcomes for patients with carbapenem-resistant Gram-negative bacterial bloodstream infection

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 57 (3)

Carbapenem-resistant Gram-negative bacterial bloodstream infection (CRGNB-BSI) has become a rapidly growing global threat with limited antibiotic opti......

Artemisinin elevates ergosterol levels of Candida albicans to synergise with amphotericin B against oral candidiasis

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 58 (3)

Oral candidiasis, especially caused by Candida albicans, is the most common fungal infection of the oral cavity. The increase in drug resistance and l......

Determination of vancomycin exposure target and individualised dosing recommendations for neonates: model-informed precision dosing

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 57 (3)

Introduction: Few studies incorporating population pharmacokinetic/pharmacodynamic (Pop-PK/PD) modelling have been conducted to quantify the exposure ......

Promoter variations associated with expression of mcr-1 gene and level of colistin resistance

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 58 (2)

Objectives: Colistin resistance mediated by plasmids for their rapid dissemination in Enterobacteriaceae is alarming. We aimed to characterize the gen......

Pharmacokinetics of colistin in cerebrospinal fluid after intraventricular administration alone in intracranial infections

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 57 (3)

The aim of this study was to investigate the pharmacokinetics of colistin in cerebrospinal fluid (CSF) after intraventricular (IVT) administration of ......

RamA upregulates multidrug resistance efflux pumps AcrAB and OqxAB in Klebsiella pneumoniae

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021; 57 (2)

Overexpression of the acrAB genes regulated by RamA and overexpression of oqxAB regulated by RarA have been reported to mediate multidrug resistance i......

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