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Instability of uracil in whole blood might affect cancer treatment with fluoropyrimidines

期刊: CLINICA CHIMICA ACTA, 2023; 538 ()

Background and aims: Measurement of plasma uracil is used before cancer treatment with fluoropyrimidines to determine if patients tolerate a full dose......

Newborn screening and genomic analysis of duchenne muscular dystrophy in Henan, China

期刊: CLINICA CHIMICA ACTA, 2023; 539 ()

Background: Duchenne Muscular Dystrophy (DMD) is a rare disorder caused by mutations in the dystrophin gene. Recent availability in treatment for DMD ......

Evaluation of reverse transcriptase-polymerase spiral reaction assay for rapid and sensitive detection of severe acute respiratory syndrome coronavirus 2

期刊: CLINICA CHIMICA ACTA, 2023; 539 ()

Background and aim: Existing real-time reverse transcriptase PCR (RT-qPCR) has certain limitations for the point -of-care detection of severe acute re......

Increased serum albumin corrected anion gap levels are associated with increased incidence of new-onset HF and poor prognosis in patients with acute myocardial infarction

期刊: CLINICA CHIMICA ACTA, 2023; 544 ()

Background: There is scant evidence on a relationship between metabolic acid load and acute myocardial infarction (AMI). We evaluated the relationship......

Clinical diagnostic value of serum soluble IL-2 receptor for stage I sarcoidosis in benign isolated mediastinal and hilar lymphadenopathy

期刊: CLINICA CHIMICA ACTA, 2023; 545 ()

Background: Serum soluble interleukin-2 receptor (sIL-2R) is recognized as a marker of T-cell activation and is abnormally elevated in sarcoidosis. Ho......

The diagnostic and prognostic value of a line immunoblot assay in Taiwanese patients with systemic sclerosis

期刊: CLINICA CHIMICA ACTA, 2023; 547 ()

Background and aims: We aimed to evaluate the diagnostic performance and prognostic value of disease-specific antibodies and anti-Ro52 using a commerc......

Saliva biomarkers in oral disease

期刊: CLINICA CHIMICA ACTA, 2023; 548 ()

Saliva is a versatile biofluid that contains a wide variety of biomarkers reflecting both physiologic and pathophysiologic states. Saliva collection i......

Circulating hyaluronidase in early pregnancy and increased risk of gestational diabetes in Chinese pregnant women: A nested case control study

期刊: CLINICA CHIMICA ACTA, 2023; 548 ()

Background and aims: To explore association of serum hyaluronidase 1 (HYAL1) level in early pregnancy with gestational diabetes mellitus (GDM), and to......

Follicular fluid extracellular vesicle miRNAs and ovarian aging

期刊: CLINICA CHIMICA ACTA, 2023; 538 ()

The decrease in the reproductive potential due to aging occurs as a gradual decline in the quantity and quality of the ovarian reserve, a phenomenon a......

Mechanisms of unusual response to lipid-lowering therapy: PCSK9 inhibition

期刊: CLINICA CHIMICA ACTA, 2023; 538 ()

The efficacy of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition has broadened lipid-lowering therapy thus providing decreased risk in......

Prognostic and predictive significance of serum soluble scavenger receptor A in acute primary basal ganglia hemorrhage: A prospective cohort study

期刊: CLINICA CHIMICA ACTA, 2023; 539 ()

Background: Scavenger receptor A (SRA) can regulate immune response and is involved in pathophysiological processes of acute brain injury. We analyzed......

Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol measurement in Familial Dysbetalipoproteinemia

期刊: CLINICA CHIMICA ACTA, 2023; 539 ()

Aim: To compare LDL-C concentrations using the Friedewald formula, the Martin-Hopkins formula, a direct assay and polyacrylamide gradient gel electrop......

Innovative model of surface-enhanced Raman spectroscopy for exosomes identification: An approach for the diagnosis of hepatocellular carcinoma

期刊: CLINICA CHIMICA ACTA, 2023; 540 ()

Background: The current hepatocellular carcinoma (HCC) diagnostic approaches lack adequate sensitivity and specificity. So, this study was performed t......

Clinical decision limits as criteria for setting analytical performance specifications for laboratory tests

期刊: CLINICA CHIMICA ACTA, 2023; 540 ()

Background: The biological (CVI), preanalytical (CVPRE), and analytical variation (CVA) are inherent to clinical laboratory testing and consequently, ......

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