期刊： GENOME BIOLOGY, 2022; 23 (1)
Haplotype-resolved de novo assembly of highly diverse virus genomes is critical in prevention, control and treatment of viral diseases. Current method......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regi......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Background The PRDM9-dependent histone methylation H3K4me3 and H3K36me3 function in assuring accurate homologous recombination at recombination hotspo......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Background Salicaceae species have diverse sex determination systems and frequent sex chromosome turnovers. However, compared with poplars, the divers......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Background: Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosi......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Advancing crop genomics requires efficient genetic systems enabled by high-quality personalized genome assemblies. Here, we introduce RagTag, a toolse......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Background Spatial transcriptomics are a set of new technologies that profile gene expression on tissues with spatial localization information. With t......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Background Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate imm......
期刊： GENOME BIOLOGY, 2022; 23 (1)
With the arrival of telomere-to-telomere (T2T) assemblies of the human genome comes the computational challenge of efficiently and accurately construc......
期刊： GENOME BIOLOGY, 2022; 23 (1)
The de Bruijn graph is a key data structure in modern computational genomics, and construction of its compacted variant resides upstream of many genom......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Background Human endogenous retroviruses (HERVs), the remnants of ancient retroviruses, account for 8% of the human genome, but most have lost their t......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Background Amphioxus are non-vertebrate chordates characterized by a slow morphological and molecular evolution. They share the basic chordate body-pl......
期刊： GENOME BIOLOGY, 2022; 23 (1)
We introduce AGAMEMNON (https://github.com/ivlachos/agamemnon) for the acquisition of microbial abundances from shotgun metagenomics and metatranscrip......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Background The human pathogen Haemophilus influenzae was the main cause of bacterial meningitis in children and a major cause of worldwide infant mort......
期刊： GENOME BIOLOGY, 2022; 23 (1)
Background Circular RNAs (circRNAs), a novel class of poorly conserved non-coding RNAs that regulate gene expression, are highly enriched in the human......
