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Epigenome-wide association study and network analysis for IgA Nephropathy from CD19(+) B-cell in Chinese Population

期刊: EPIGENETICS, ; ()

IgA nephropathy (IgAN) is the most common primary glomerular disease in China and worldwide. The proliferation of B cells is known to be associated wi......

Hypermethylation of PI3K-AKT signalling pathway genes is associated with human neural tube defects

期刊: EPIGENETICS, ; ()

Neural tube defects (NTDs) are a group of common and severe congenital malformations. The PI3K-AKT signalling pathway plays a crucial role in the neur......

Up-regulation of LINC00619 promotes apoptosis and inhibits proliferation, migration and invasion while promoting apoptosis of osteosarcoma cells through inactivation of the HGF-mediated PI3K-Akt signalling pathway

期刊: EPIGENETICS, ; ()

This study is performed to evaluate the role of long noncoding RNA (lncRNA) LINC00619 in osteosarcoma through the PI3K-Akt signalling pathway by bindi......

Identification of differential DNA methylation alterations of ovarian cancer in peripheral whole blood based on within-sample relative methylation orderings

期刊: EPIGENETICS, ; ()

Leukocyte cell proportion changes affect the detection of cancer-associated aberrant DNA methylation alterations in peripheral blood samples. We aimed......

Dietary inclusion of plant ingredients induces epigenetic changes in the intestine of zebrafish

期刊: EPIGENETICS, 2020; 15 (10)

Epigenetic modifications, such as DNA methylation, can be regulated by nutrition and dietary factors. There has been a large increase in the use of su......

Overexpression of human-derived DNMT3A induced intergenerational inheritance of DNA methylation and gene expression variations in rat brain and testis

期刊: EPIGENETICS, 2020; 15 (10)

In mammals, DNA methylation patterns are established by various types of DNA methyltransferases and can be stably passed on during cell division, thus......

A novel CpG-methylation-based nomogram predicts survival in colorectal cancer

期刊: EPIGENETICS, 2020; 15 (11)

Aberrant DNA methylation is significantly associated with the prognosis of patients with colorectal cancer (CRC). Therefore, the aim of this study was......

Osteoporosis- and obesity-risk interrelationships: an epigenetic analysis of GWAS-derived SNPs at the developmental gene TBX15

期刊: EPIGENETICS, 2020; 15 (6-7)

A major challenge in translating findings from genome-wide association studies (GWAS) to biological mechanisms is pinpointing functional variants beca......

Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma

期刊: EPIGENETICS, 2020; 15 (6-7)

The aim of our study was to explore the relationship between the methylation status of the alpha-1A adrenergic receptor (ADRA1A) gene and hepatocellul......

Aberrant hydroxymethylation of ANGPTL4 is associated with selective intrauterine growth restriction in monochorionic twin pregnancies

期刊: EPIGENETICS, 2020; 15 (8)

Selective intrauterine growth restriction (sIUGR) is a severe complication in monochorionic (MC) twin pregnancies, and it carries increased risks of p......

Promoter hypermethylation of PIWI/piRNA pathway genes associated with diminished pachytene piRNA production in bovine hybrid male sterility

期刊: EPIGENETICS, 2020; 15 (9)

Hybrid male sterility (HMS) is a postzygotic reproductive isolation mechanism that enforces speciation. A bovine example of HMS is the yattle (also ca......

Loss of KMT2D induces prostate cancer ROS-mediated DNA damage by suppressing the enhancer activity and DNA binding of antioxidant transcription factor FOXO3

期刊: EPIGENETICS, 0; ()

Histone methyltransferase KMT2D has diverse functions and distinct mechanisms in different cancers. Although we have previously found KMT2D serves as ......

An in vitro attempt at precision toxicology reveals the involvement of DNA methylation alteration in ochratoxin A-induced G0/G1 phase arrest

期刊: EPIGENETICS, 2020; 15 (1-2)

Precision toxicology evaluates the toxicity of certain substances by isolating a small group of cells with a typical phenotype of interest followed by......

Essential roles of HDAC1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development

期刊: EPIGENETICS, 0; ()

Epigenetic modifications, including DNA methylation and histone modifications, are reprogrammed considerably following fertilization during mammalian ......

DNA hydroxymethylation increases the susceptibility of reactivation of methylated P16 alleles in cancer cells

期刊: EPIGENETICS, 0; ()

It is well established that 5-methylcytosine (5mC) in genomic DNA of mammalian cells can be oxidized into 5-hydroxymethylcytosine (5hmC) and other der......

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